Abstract
There is strong histoincompatibility between the rat and the mouse such that grafts of rat skin (1) or primarily vascularized hearts (2) placed in mice undergo acute rejection about 5 to 9 days after transplantation. In the case of skin grafts, which have been more thoroughly studied, this prompt rejection has been shown to occur in all of a large number of mouse strains that have been tested (3). If, however, the recipients of skin grafts receive a brief course of treatment with anti-lymphocyte serum (ALS)4 at the time of grafting, survival of the grafts is prolonged and the extent of prolongation varies among the recipient strains to a surprising degree (3). That this latter phenomenon is not restricted to skin grafts is demonstrated by the results obtained with primarily vascularized xenografts of hearts as described in this report.
Mice were purchased from the Jackson Laboratory, Bar Harbor, Maine.
Footnotes
- Received November 27, 1978.
- Accepted May 29, 1979.
- Copyright © 1979 by The American Association of Immunologists, Inc.
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