Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

Potentiation of IgE Response in Vitro by T Cells from Rats Infected with Nippostrongylus Brasiliensis

Masaki Suemura and Kimishige Ishizaka
J Immunol August 1, 1979, 123 (2) 918-924;
Masaki Suemura
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kimishige Ishizaka
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The effect of T cells from rats infected with Nippostrongylus brasiliensis (Nb) on the IgE response was studied by using an in vitro system. Mesenteric lymph node cells from DNP-OA (dinitrophenyl derivatives of ovalbumin)-primed rats were cultured with DNP-OA or DNP-HSA in the presence of T or B cells from Nb-infected rats. It was found that T cells from the infected rat, but not normal T cells, selectively enhanced the IgE-forming cell response of DNP-OA primed cells to homologous antigen without affecting the IgG-forming cell response. The enhancement of the IgE response requires carrier-primed T cells; T cells from Nb-infected animals failed to enhance the Ig-forming cell response of DNP-OA primed cells to DNP-HSA. Culture supernatants of T cells from Nb-infected rats selectively enhanced the IgE response of DNP-OA primed cells to homologous antigen without affecting IgG response. The IgE-potentiating factor present in the unstimulated cultures is different from T cell-replacing factor(s), which was obtained by stimulation of antigen-primed T cells with antigen. When T cells from Nb-infected rats were incubated with Nb antigen, culture supernatant of the cells enhanced both IgE and IgG responses of DNP-OA primed cells to DNP-OA or DNP-HSA. It was also found that the molecular size of IgE-potentiating factor was significantly smaller than T cell-replacing factor. The results suggested that an optimal IgE response may require two subsets of T cells; one is carrier-specific T cells, which are common for all isotypes, and another subset is cells forming IgE-potentiating factor.

Footnotes

  • ↵1 This work was supported by research Grants AI-14784 and AI-11202 from the United States Public Health Service. This paper is Publication No. 350 from the O'Neill Laboratories at the Good Samaritan Hospital.

  • Received April 17, 1979.
  • Accepted May 22, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

The Journal of Immunology
Vol. 123, Issue 2
1 Aug 1979
  • Table of Contents
  • Table of Contents (PDF)
  • Advertising (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Potentiation of IgE Response in Vitro by T Cells from Rats Infected with Nippostrongylus Brasiliensis
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Potentiation of IgE Response in Vitro by T Cells from Rats Infected with Nippostrongylus Brasiliensis
Masaki Suemura, Kimishige Ishizaka
The Journal of Immunology August 1, 1979, 123 (2) 918-924;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Potentiation of IgE Response in Vitro by T Cells from Rats Infected with Nippostrongylus Brasiliensis
Masaki Suemura, Kimishige Ishizaka
The Journal of Immunology August 1, 1979, 123 (2) 918-924;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Different Responses of B Lymphocyte Colony-Forming Cells in Bone Marrow and Spleen of Mice Injected with Bacterial Cell-Wall Components
  • Immunopotentiating Effects of Amphotericin B
  • T Cell Regulation of Polyclonal B Cell Responsiveness
Show more Cellular Immunology

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • FAR 889
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2022 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606