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Structural Studies on Induced Antibodies with Defined Idiotypic Specificities

VI. Amino Terminal Sequences of the Heavy and Light Chain Variable Regions of anti-p-azophenylarsonate Antibodies from A/J Mice Suppressed for a Cross-Reactive Idiotype

J. Donald Capra, Shyr-Te Ju and Alfred Nisonoff
J Immunol September 1, 1978, 121 (3) 953-957;
J. Donald Capra
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Shyr-Te Ju
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Alfred Nisonoff
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Abstract

Previous studies in this series have been directed toward the elucidation of the heavy and light chain variable region structures of antibodies raised in A/J mice to the p-azophenylarsonate (Ar) hapten, certain of which bear a cross-reacting idiotype. The present study concerns an analysis of anti-Ar antibodies that arise in A/J mice suppressed for a cross-reacting idiotype. The results indicate that when an idiotype is suppressed and the animal subsequently hyperimmunized, the resultant antibodies are “deviated” into different V-region subgroups, both in the heavy and light polypeptide chains. The study presents the first primary structural analysis of a humoral immune response that has been manipulated by an idiotypic reagent.

Footnotes

  • ↵1 This work was supported in part by the National Institutes of Health Grants AI12127, AI12796, AI12895, and AI12907 and the National Science Foundation Grant PCM76-22411.

  • Received May 2, 1978.
  • Accepted June 9, 1978.
  • Copyright © 1978 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 121, Issue 3
1 Sep 1978
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Structural Studies on Induced Antibodies with Defined Idiotypic Specificities
J. Donald Capra, Shyr-Te Ju, Alfred Nisonoff
The Journal of Immunology September 1, 1978, 121 (3) 953-957;

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Structural Studies on Induced Antibodies with Defined Idiotypic Specificities
J. Donald Capra, Shyr-Te Ju, Alfred Nisonoff
The Journal of Immunology September 1, 1978, 121 (3) 953-957;
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Print ISSN 0022-1767        Online ISSN 1550-6606