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Target Antigens for H-2-Restricted Vesicular Stomatitis Virus-Specific Cytotoxic T Cells

R. M. Zinkernagel, A. Althage and J. Holland
J Immunol August 1, 1978, 121 (2) 744-748;
R. M. Zinkernagel
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A. Althage
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J. Holland
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Abstract

Cytotoxic thymus-derived lymphocytes from mice infected with vesicular stomatitis virus (VSV) are H-2 restricted and virus specific for the Indiana and New Jersey strains of VSV. VSV-Indiana-immune T cells can lyse target cells infected with the temperature sensitive (ts) mutant ts 045 about 30 times better when target cell infection occurs at the permissive rather than the nonpermissive temperature. Since this mutant fails to express the glycoprotein at the cell surface when grown at the nonpermissive temperature, our results support the view that the viral glycoprotein is involved in defining the major target antigen for VSV-specific T cells. However, the tl 17 mutant that expresses a mutant glycoprotein at the cell surface was lysed, suggesting that the expressed mutated glycoprotein can cross-react with Indiana wild-type glycoprotein. Targets infected at the nonpermissive temperature with VSV ts G31 (mutant in the matrix protein) are still susceptible to T cell-mediated lysis but at a lower level of sensitivity. These results are compatible with the interpretation that for VSV-specific T cell lysis of infected target cells, the viral glycoprotein is a major target antigen and must be expressed, and that the matrix protein plays a lesser role, probably by indirectly influencing glycoprotein configuration at the cell surface.

Footnotes

  • ↵1 This work was supported by Public Health Service Grants Al-07007 and Al-13779 (R. M. Z.) and AI-14627 (J. H.).

  • ↵2 This is Publication No. 1525 from the Immunology Departments, Scripps Clinic and Research Foundation, La Jolla, California 92037.

  • Received February 15, 1978.
  • Accepted May 4, 1978.
  • Copyright © 1978 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 121, Issue 2
1 Aug 1978
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Target Antigens for H-2-Restricted Vesicular Stomatitis Virus-Specific Cytotoxic T Cells
R. M. Zinkernagel, A. Althage, J. Holland
The Journal of Immunology August 1, 1978, 121 (2) 744-748;

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Target Antigens for H-2-Restricted Vesicular Stomatitis Virus-Specific Cytotoxic T Cells
R. M. Zinkernagel, A. Althage, J. Holland
The Journal of Immunology August 1, 1978, 121 (2) 744-748;
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Print ISSN 0022-1767        Online ISSN 1550-6606