Abstract
Viable eosinophils from normal human peripheral blood were separated by sedimentation through a nutrient-enriched linear gradient of sodium hypaque. Ingestion experiments with these cells showed that eosinophils would phagocytose latex beads coated with a mixture of allergen and corresponding allergic human serum. The stimulatory activity of the allergic serum correlated with the IgG fraction and not with those properties associated with IgE. Eosinophils isolated from allergic donors were found to be inferior in their phagocytic ability when compared with eosinophils from normal cell donors.
Footnotes
-
↵2 Recipient of National Institutes of Health Special Fellowship 5 F 12 GM 56050.
-
↵3 Correspondence: Dr. David E. Normansell, Department of Pathology, University of Virginia Medical School, Charlottesville, Virginia 22908.
-
↵1 This work was supported in part by United States Public Health Service Grant AM 13449. The research was approved by the University of Virginia Human Investigation Committee.
- Received February 17, 1978.
- Accepted May 10, 1978.
- Copyright © 1978 by The American Association of Immunologists, Inc.
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
Log in using your username and password
In this issue
