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Sharing of Ia Antigens Between Species

II. Molecular Localization of Shared Ia Determinants Implies the Existence of More Than One I Sublocus of the Rat MHC

Nobukata Shinohara, Joan K. Lunney and David H. Sachs
J Immunol August 1, 1978, 121 (2) 637-640;
Nobukata Shinohara
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Joan K. Lunney
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David H. Sachs
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Abstract

A mouse alloantiserum B10.D2 anti-B10.BR (H-2d anti-H-2k) cross-reacted with rat lymphocyte surface glycoproteins with characteristics of Ia antigens. Sequential precipitation analysis on solubilized radiolabeled LEW rat lymphocyte antigens with this cross-reactive mouse alloantiserum and the rat alloantiserum BN anti-LEW (Ag-B3 anti-Ag-B1) revealed that the Ia-like antigen detected by the mouse alloantiserum also reacted with the rat anti-Ia antibodies. It was further shown that the rat alloantiserum also detected another set of Ia-like antigens that did not cross-react with the mouse alloantibody. Precipitation analysis with congenic rat strains confirmed that all Ia-like antigens precipitated by the rat alloantibody were encoded by Ag-B linked genes. Thus the shared Ia-like antigen must also be the product of Ag-B-linked gene(s) or be physically associated with such products. In addition, molecules bearing shared antigenic determinants were separable from at least some of the Ia-like antigens detected by the rat alloantiserum, possibly suggesting the existence of more than one sublocus coding for Ia antigens within the rat MHC.

  • Received March 2, 1978.
  • Accepted May 18, 1978.
  • Copyright © 1978 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 121, Issue 2
1 Aug 1978
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Sharing of Ia Antigens Between Species
Nobukata Shinohara, Joan K. Lunney, David H. Sachs
The Journal of Immunology August 1, 1978, 121 (2) 637-640;

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Sharing of Ia Antigens Between Species
Nobukata Shinohara, Joan K. Lunney, David H. Sachs
The Journal of Immunology August 1, 1978, 121 (2) 637-640;
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