Abstract
A cellular infiltrate rich in basophils was observed in chickens in skin sites injected locally with the mitogen PHA. These infiltrating metachromatically granulated cells exhibited features common to mast cells of some species (monolobed nucleus), but also resembled basophils of other species in that they circulated in the blood, and they responded to the PHA mitogen by infiltrating skin test sites. Previous literature suggests that the chicken has a single metachromatic granulated cell and our data support this notion. PHA, a known T cell mitogen, may act by causing the stimulated T lymphocyte to produce a lymphokine that is responsible for the attraction of basophils to the test site.
Footnotes
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↵1 This work was supported by United States Public Health Service Grants CA-19141 and AI-10895 and American Cancer Society Grant IM-44.
- Received October 26, 1976.
- Copyright © 1977 by The American Association of Immunologists, Inc.
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