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Histamine-Induced Inhibition of Normal Human Basophil Chemotaxis to C5a

Michael A. Lett-Brown and Edward J. Leonard
J Immunol March 1, 1977, 118 (3) 815-818;
Michael A. Lett-Brown
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Edward J. Leonard
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Abstract

Histamine in concentrations as low as 10-8 M inhibited the chemotactic response of normal human basophils to C5a. Histamine had no effect on basophil chemotaxis to lymphocyte-derived chemotactic factor. Histamine inhibition of basophil chemotaxis to C5a was prevented by metiamide, a drug which blocks H2 receptors for histamine. Since the accumulation of basophils in delayed cutaneous basophilic hypersensitivity (CBH) reactions may occur in part because of chemotaxis to C5a, and since C5a can induce histamine release, histamine inhibition of chemotaxis may limit basophil infiltration in CBH lesions.

Footnotes

  • ↵1 Visiting Fellow, National Institutes of Health, Bethesda, Maryland.

  • Received September 3, 1976.
  • Copyright © 1977 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 118, Issue 3
1 Mar 1977
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Histamine-Induced Inhibition of Normal Human Basophil Chemotaxis to C5a
Michael A. Lett-Brown, Edward J. Leonard
The Journal of Immunology March 1, 1977, 118 (3) 815-818;

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Histamine-Induced Inhibition of Normal Human Basophil Chemotaxis to C5a
Michael A. Lett-Brown, Edward J. Leonard
The Journal of Immunology March 1, 1977, 118 (3) 815-818;
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Print ISSN 0022-1767        Online ISSN 1550-6606