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Immune Response in the Hamster

VIII. Ig Class Differences in Susceptibility to Tolerance Induction

J. L. Portis and J. E. Coe
J Immunol September 1, 1976, 117 (3) 835-840;
J. L. Portis
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J. E. Coe
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Abstract

A hemolytic plaque assay was used to quantitate the antibody response of the Syrian hamster after immunization with hen egg albumin (HEA). Whereas HEA in complete Freund's adjuvant (HEA-CF) induced a prolonged heterogeneous (IgM, IgG1 and IgG2) antibody response, the response to soluble HEA in saline (HEA-S) differed in that: 1) both the primary and secondary responses were restricted to the IgG1 class; 2) the IgG1 primary response was cyclical with PFC peaks on days 9 and 16; 3) although an anamnestic secondary response was demonstrated, no further augmentation was noted after tertiary and quaternary boosters; 4) the booster response was transient reaching a peak after 48 hr and declining to low levels within 7 days. Adoptive transfer of lymph node cells to irradiated recipients followed by challenge with HEA-CF revealed: 1) that HEA-S-treated donor cells were primed for an IgG1 response because anamnesis was seen 7 days after challenge, yet on day 21, IgG1 PFC were 20-fold less than that of controls; 2) recipients of HEA-S treated cells showed profound suppression of both IgM and IgG2 PFC on days 14 and 21. These studies indicate that soluble antigen induced in hamsters a state of complete tolerance of IgM and IgG2 classes whereas the anamnestic response of the IgG1 class remained intact.

  • Received March 15, 1976.
  • Copyright, 1976, by The Williams & Wilkins Company
  • Copyright © 1976 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 117, Issue 3
1 Sep 1976
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Immune Response in the Hamster
J. L. Portis, J. E. Coe
The Journal of Immunology September 1, 1976, 117 (3) 835-840;

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Immune Response in the Hamster
J. L. Portis, J. E. Coe
The Journal of Immunology September 1, 1976, 117 (3) 835-840;
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