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Tolerance and Contact Sensitivity to DNFB in Mice

VI. Inhibition of Afferent Sensitivity by Suppressor T Cells in Adoptive Tolerance

John W. Moorhead
J Immunol September 1, 1976, 117 (3) 802-806;
John W. Moorhead
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Abstract

Tolerance in contact sensitivity to DNFB can be adoptively transferred to normal mice with lymph node cells from tolerant donors. This tolerance is antigen specific and is mediated by T cells, i.e., “suppressor” T cells. Experiments were carried out to investigate the mechanism(s) by which the suppressor T cells induce tolerance to DNFB contact sensitivity. The suppressor cells were effective only if they were present during the early stages of the afferent limb of sensitization. As measured by DNA synthesis, cell proliferation in the draining lymph nodes of recipients of suppressor cells was found to be significantly less than in control animals indicating that the suppressor cells acted, at least in part, by limiting or inhibiting DNFB-induced cell proliferation. This inhibition was shown to be antigen specific since the DNFB suppressor cells did not inhibit cell proliferation induced by oxazolone, an unrelated contact sensitizer. The ability to DNFB tolerant cells to block afferent sensitization pathways differs from the mechanism of tolerance to picryl chloride, reported by others, where efferent pathways are blocked.

Footnotes

  • ↵1 This work was supported in part by United States Public Health Service Grant AI-12685.

  • Received March 22, 1976.
  • Copyright, 1976, by The Williams & Wilkins Company
  • Copyright © 1976 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 117, Issue 3
1 Sep 1976
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Tolerance and Contact Sensitivity to DNFB in Mice
John W. Moorhead
The Journal of Immunology September 1, 1976, 117 (3) 802-806;

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Tolerance and Contact Sensitivity to DNFB in Mice
John W. Moorhead
The Journal of Immunology September 1, 1976, 117 (3) 802-806;
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Print ISSN 0022-1767        Online ISSN 1550-6606