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Immunologic Hyporesponsiveness in Man to Group C Meningococcal Polysaccharide

Malcolm S. Artenstein and Brenda L. Brandt
J Immunol July 1, 1975, 115 (1) 5-7;
Malcolm S. Artenstein
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Brenda L. Brandt
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Abstract

By using a hemagglutination-inhibition assay, certain lots of purified group A meningococcal polysaccharide vaccines were found to contain trace amounts of group C polysaccharide (0.032 to 0.128%). Young adult human volunteers inoculated with these vaccines showed a very poor group C serum anti-polysaccharide antibody response as determined by a radioactive antigen-binding assay. Two weeks later volunteers were given a 50-µg subcutaneous injection of purified group C polysaccharide. Serum specimens obtained 1 month later showed a significant suppression of group C antibody response in comparison with subjects who had initially received group A vaccines which were free of group C antigen. The observed hyporesponsiveness may represent an example of immunologic tolerance in man.

  • Received February 14, 1975.
  • Copyright, 1975, by The Williams & Wilkins Company
  • Copyright © 1975 by The American Association of Immunologists, Inc.
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The Journal of Immunology
Vol. 115, Issue 1
1 Jul 1975
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Immunologic Hyporesponsiveness in Man to Group C Meningococcal Polysaccharide
Malcolm S. Artenstein, Brenda L. Brandt
The Journal of Immunology July 1, 1975, 115 (1) 5-7;

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Immunologic Hyporesponsiveness in Man to Group C Meningococcal Polysaccharide
Malcolm S. Artenstein, Brenda L. Brandt
The Journal of Immunology July 1, 1975, 115 (1) 5-7;
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Print ISSN 0022-1767        Online ISSN 1550-6606