Abstract
Human β2microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more β2microglobulin than thymocytes although hydrocortisoneresistant thymocytes resemble spleen cells in this regard. The β2microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for β2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.
Footnotes
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↵1 This work was supported by United States Public Health Service Grants AI 09758, CA 15895, AI 12136, and American Heart Association Grant 74856.
- Received September 16, 1974.
- Copyright © 1975 by The American Association of Immunologists, Inc.
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