Abstract
The low molecular weight mast cell activator, polymyxin B, has been covalently bound to an insoluble matrix of Sepharose 4B. It has been demonstrated that mast cells in preparations of rat peritoneal cells bind to Sepharose 4B-polymyxin B beads but not to control beads. The bound cells are stimulated to degranulate by this interaction at the cell membrane with the resultant release of biogenic amines.
Footnotes
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↵2 Supported by United States Public Health Service Training Grant 5-TO1-GM00683-13.
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↵3 Recipient of United States Public Health Service Career Development Award GM42567-04.
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↵1 This is Publication 761 from the Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California. This work was supported by the United States Public Health Service Grant AI-07007, the American Heart Association, the Council for Tobacco Research, and GMS Grant GM 19322-02.
- Received July 15, 1974.
- Copyright © 1975 by The American Association of Immunologists, Inc.
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