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Induction of Lymphocyte Cytotoxicity by Modification of the Effector or Target Cells with Periodate or with Neuraminidase and Galactose Oxidase

Abraham Novogrodsky
J Immunol March 1, 1975, 114 (3) 1089-1093;
Abraham Novogrodsky
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Abstract

Treatment of mouse spleen cells with periodate (NaIO4) or with neuraminidase and galactose oxidase (NAGO) induces blastogenesis and renders the cells cytotoxic to mastocytoma (P815) target cells. Treatment of target cells (P815 cells and turkey erythrocytes) with NaIO4 or with NAGO renders them susceptible to cytolysis by untreated mouse spleen cells. The cytotoxicity induced by NaIO4 is reduced upon reacting the NaIO4-treated, effector or target cells with borohydride or hydroxylamine. Thus the formation of free surface aldehydes on either the effector or target cell induced a cytotoxic effect. It is postulated that cross-linkage via a Schiff base between effector and target cell initiates the cytotoxic effect. Cytotoxicity induced by NaIO4 or NAGO is immunologically nonspecific and is independent of major antigenic differences between effector and target cells. Phagocytic cells are not involved in NaIO4-or NAGO-induced cytotoxicity toward P815 target cells.

  • Received December 2, 1974.
  • Copyright © 1975 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 114, Issue 3
1 Mar 1975
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Induction of Lymphocyte Cytotoxicity by Modification of the Effector or Target Cells with Periodate or with Neuraminidase and Galactose Oxidase
Abraham Novogrodsky
The Journal of Immunology March 1, 1975, 114 (3) 1089-1093;

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Induction of Lymphocyte Cytotoxicity by Modification of the Effector or Target Cells with Periodate or with Neuraminidase and Galactose Oxidase
Abraham Novogrodsky
The Journal of Immunology March 1, 1975, 114 (3) 1089-1093;
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Print ISSN 0022-1767        Online ISSN 1550-6606