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Specific Stimulatory and Cytotoxic Effects of Lymphocytes Sensitized in Vitro to Either Alloantigens or Tumor Antigens

Mary Ann Kall and Ingegerd Hellström
J Immunol March 1, 1975, 114 (3) 1083-1088;
Mary Ann Kall
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Ingegerd Hellström
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Abstract

Lymph node cells (LNC) or spleen cells from normal BALB/c mice were sensitized in vitro by co-cultivation with mitomycin C-treated allogeneic sarcoma cells, and their reactivity measured with a microcytotoxicity assay. Following 5 days of sensitization, a specific cytotoxic effect against tumor cells carrying the sensitizing alloantigens was observed; this is in agreement with previously published findings. Lymphoid cells tested after 3 days of sensitization, however, specifically increased the number of target cells remaining in the Microtest plates at the conclusion of the microcytotoxicity assays.

LNC from normal BALB/c mice were also sensitized in vitro against tumor specific antigens using four different methylcholanthrene-induced sarcomas of BALB/c origin. After 6 days of sensitization the LNC were specifically cytotoxic for the immunizing tumor cell line. After 3 days of sensitization, however, the LNC gave a specific increase of the number of remaining target tumor cells.

Footnotes

  • ↵2 This investigator was supported in part as a Graduate Research Trainee (Ca05040), National Cancer Institute.

  • ↵1 This investigation was supported by Grants CA 10188 and CA 10189 from the National Institutes of Health, by Grant 1C-56D from the American Cancer Society, by Contract NIH-NCI-71-2171 within the Virus Cancer Program of the National Cancer Institute, and by Contract NO1 CB 23887 from the National Cancer Institute.

  • Received December 6, 1974.
  • Copyright © 1975 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 114, Issue 3
1 Mar 1975
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Specific Stimulatory and Cytotoxic Effects of Lymphocytes Sensitized in Vitro to Either Alloantigens or Tumor Antigens
Mary Ann Kall, Ingegerd Hellström
The Journal of Immunology March 1, 1975, 114 (3) 1083-1088;

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Specific Stimulatory and Cytotoxic Effects of Lymphocytes Sensitized in Vitro to Either Alloantigens or Tumor Antigens
Mary Ann Kall, Ingegerd Hellström
The Journal of Immunology March 1, 1975, 114 (3) 1083-1088;
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