Abstract
Histamine release from rat mast cells by dextran and by antigen under various conditions was studied in terms of the rate of release and the duration of release, which together determined the total amount released. Reducing the concentration of the releasing agent decreased the rate of release without greatly affecting its duration. Reducing the temperature also decreased the rate, but prolonged the duration. Under all of the various conditions, release stopped as the cells became desensitized to the releasing agent. It appeared, therefore, that the rate of desensitization controlled the duration of release.
Footnotes
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↵1 Mailing Address: James H. Baxter, M.D., Bldg. 10, Room 5N-310, National Institutes of Health, Bethesda, Maryland 20014.
- Received July 8, 1974.
- Copyright © 1975 by The American Association of Immunologists, Inc.
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