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Heavy Chain-Producing Variants of a Mouse Myeloma Cell Line

Sherie L. Morrison and Matthew D. Scharff
J Immunol February 1, 1975, 114 (2 Part 1) 655-659;
Sherie L. Morrison
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Matthew D. Scharff
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Abstract

Eleven variants producing only heavy (H) chains have been isolated from the P3 cell line after mutagenesis with either ICR-191 or nitrosoguanidine. The H chains produced by these variants are similar both in molecular weight and by peptide maps with the parental H chain. H chains dimerize intreacellularly, are not secreted but persist as stable cytoplasmic proteins. No evidence for the continued synthesis of light (L) chains or L chain fragments has been found in these variants. These studies show that, in the P3 cell line, the synthesis of H chains can continue in the absence of detectable L chain synthesis.

Footnotes

  • ↵1 This work was supported by grants from the National Institutes of Health (AI 5231, AI 10702), the National Science Foundation (GB 29560), and the American Cancer Society and Public Health Service Training Grant 5T01 GM 2209.

  • Received July 29, 1974.
  • Copyright © 1975 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 114, Issue 2 Part 1
1 Feb 1975
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Heavy Chain-Producing Variants of a Mouse Myeloma Cell Line
Sherie L. Morrison, Matthew D. Scharff
The Journal of Immunology February 1, 1975, 114 (2 Part 1) 655-659;

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Heavy Chain-Producing Variants of a Mouse Myeloma Cell Line
Sherie L. Morrison, Matthew D. Scharff
The Journal of Immunology February 1, 1975, 114 (2 Part 1) 655-659;
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Print ISSN 0022-1767        Online ISSN 1550-6606