Abstract
Several cellfree ascitic fluids were tested for their influence on the trapping of lymphocytes in peripheral lymph nodes after subcutaneous antigen administration. Fluid from three ascitic tumors cultivated in syngeneic mice diminished the trapping response significantly. Fluid from one of these ascitic tumors cultivated in allogeneic mice showed no inhibition of trapping. Syngeneic normal mouse serum did not significantly affect the trapping phenomenon. It was concluded that syngeneic ascitic fluids contain a substance capable of inhibiting lymphocyte trapping.
Footnotes
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↵1 This work was supported by Public Health Service Research Grant AI09341 and Training Grant AI-00082 both from the National Institute of Allergy and Infectious Diseases and a Research Development Fund award from Stanford University.
- Received August 26, 1974.
- Copyright © 1975 by The American Association of Immunologists, Inc.
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