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Neural Antigens and Induction of Myelination Inhibition Factor

Fredrick J. Seil, Marian W. Kies and Martha Bacon
J Immunol February 1, 1975, 114 (2 Part 1) 630-634;
Fredrick J. Seil
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Marian W. Kies
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Martha Bacon
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Abstract

Rabbits were sensitized or immunized with a variety of central nervous system antigens, including bovine spinal cord, bovine, monkey, human, guinea pig, rabbit, and rat S myelin basic proteins, and a polypeptide derived from guinea pig basic protein. The animals were observed for development of experimental allergic encephalomyelitis, and their sera were collected at varying intervals after inoculation and evaluated for presence of precipitating anti-basic protein antibody and for their ability to inhibit myelin formation in cerebellar tissue cultures. The resulting complete dissociation between development of experimental allergic encephalomyelitis, the presence of antibasic protein antibody and the occurrence of myelination inhibition factor suggests that myelination inhibition factor is not involved in the pathogenesis of experimental allergic encephalomyelitis, and argues against a role for anti-basic protein antibody as an antimyelin factor in vitro.

  • Received October 31, 1974.
  • Copyright © 1975 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 114, Issue 2 Part 1
1 Feb 1975
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Neural Antigens and Induction of Myelination Inhibition Factor
Fredrick J. Seil, Marian W. Kies, Martha Bacon
The Journal of Immunology February 1, 1975, 114 (2 Part 1) 630-634;

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Neural Antigens and Induction of Myelination Inhibition Factor
Fredrick J. Seil, Marian W. Kies, Martha Bacon
The Journal of Immunology February 1, 1975, 114 (2 Part 1) 630-634;
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