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Cyclic AMP, ATP, and Reversed Anaphylactic Histamine Release from Rat Mast Cells

Michael Kaliner and K. Frank Austen
J Immunol February 1, 1974, 112 (2) 664-674;
Michael Kaliner
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K. Frank Austen
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Abstract

Reversed anaphylactic histamine release by rabbit (Rab) anti-Rat Fab was independent of serum factors and was established as being noncytolytic in that challenged isolated mast cells still retained incorporated 42K and excluded trypan blue dye after releasing histamine. The release reaction involved the activation of a diisopropyl fluorophosphate (DFP)-sensitive esterase and required energy utilization. Prostaglandin E1 (PGE1) consistently produced a dose-related increase in the mast cell content of cyclic 3′,5′-adenosine monophosphate (cyclic AMP) which at the optimal concentration was 2 to 3 times the average baseline of 4.71 pmoles/106 mast cells (range -1 to 10 pmoles/106 mast cells). Aminophylline and PGE1 alone each inhibited Rab anti-Rat Fab-induced histamine release with concomitant increases in cyclic AMP, and the combination of these agents had a synergistic effect on both parameters. The inhibition of histamine release by the endogenous accumulation of cyclic AMP was reproduced by the exogenous administration of dibutyryl cyclic AMP. The interaction of Rab anti-Rat Fab with isolated mast cells resulted in a depletion of the cellular levels of cyclic AMP, ATP, and calcium in association with histamine release. Although these consequences of membrane perturbation may be unrelated, it seems more likely that they are interrelated and intrinsic to reversed anaphylactic histamine release.

Footnotes

  • ↵2 Postdoctoral fellow of the National Tuberculosis and Respiratory Disease Association.

  • ↵1 This work was supported by Grants AI-07722, RR-05669, and AI-10356 from the National Institutes of Health.

  • Received October 2, 1973.
  • Copyright, 1974, by The Williams & Wilkins Company
  • Copyright © 1974 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 112, Issue 2
1 Feb 1974
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Cyclic AMP, ATP, and Reversed Anaphylactic Histamine Release from Rat Mast Cells
Michael Kaliner, K. Frank Austen
The Journal of Immunology February 1, 1974, 112 (2) 664-674;

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Cyclic AMP, ATP, and Reversed Anaphylactic Histamine Release from Rat Mast Cells
Michael Kaliner, K. Frank Austen
The Journal of Immunology February 1, 1974, 112 (2) 664-674;
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