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Evolution of the Immune Response to Type III and VIII Pneumococcal Polysaccharides

Francis W. Chen, A. Donny Strosberg and Edgar Haber
J Immunol January 1, 1973, 110 (1) 98-106;
Francis W. Chen
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A. Donny Strosberg
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Edgar Haber
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Abstract

The variability of the immune response of 30 rabbits to the type III and of 40 rabbits to the type VIII pneumococci was studied. Sixty-seven out of 70 animals produced, at one time or another, antibodies of restricted electrophoretic mobility, but no general pattern could be defined. One animal produced a single antibody species throughout the six months of immunization. The homogeneity of this antibody population was evidenced by a unique amino acid sequence of the N-terminal part of the light chain. Only an interplay of several competing and cooperating mechanisms could account for the very diverse nature of the immune response observed in these experiments.

Footnotes

  • ↵2 Recipient of a fellowship from the Albert J. Ryan Trust.

  • ↵3 On leave from the Free University Brussels. Recipient of a long-term E.M.B.O. (European Molecular Biology Organization) fellowship.

  • ↵4 Requests for reprints should be addressed to Dr. Edgar Haber, Cardiac Unit, Massachusetts General Hospital, Boston, Massachusetts 02114.

  • ↵1 This work was supported by National Institutes of Health Grant AI-04967.

  • Received August 8, 1972.
  • Copyright, 1972, by The Williams & Wilkins Company
  • Copyright © 1973 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 110, Issue 1
1 Jan 1973
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Evolution of the Immune Response to Type III and VIII Pneumococcal Polysaccharides
Francis W. Chen, A. Donny Strosberg, Edgar Haber
The Journal of Immunology January 1, 1973, 110 (1) 98-106;

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Evolution of the Immune Response to Type III and VIII Pneumococcal Polysaccharides
Francis W. Chen, A. Donny Strosberg, Edgar Haber
The Journal of Immunology January 1, 1973, 110 (1) 98-106;
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Print ISSN 0022-1767        Online ISSN 1550-6606