Genetic Control of the Immune Response in Mice. IV. Relationship Between Graft vs Host Reactivity and Possession of the High Tumor Genotypes A^ya and A^vya

Summary

The graft vs host (GVH) reactivity of spleen cells from mice possessing the high tumor genotypes A^ya and A^vya was compared with the reactivity of spleen cells from histocompatible nonagouti animals. Spleen cells from YBR aa mice caused significantly greater GVH reactions than YBR A^ya cells, and spleen cells from C57BL/6J aa donors were more reactive in GVH assays than cells from C57BL/6J A^vya mice. These results suggest that reduced immune responsiveness may be involved in the tumor susceptibility of A^ya and A^vya mice.