Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
The Journal of Immunology
  • Other Publications
    • American Association of Immunologists
    • ImmunoHorizons
  • Subscribe
  • Log in
The Journal of Immunology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Next in The JI
    • Archive
    • Brief Reviews
    • Pillars of Immunology
    • Translating Immunology
    • Most Read
    • Top Downloads
    • Annual Meeting Abstracts
  • COVID-19/SARS/MERS Articles
  • Info
    • About the Journal
    • For Authors
    • Journal Policies
    • Influence Statement
    • For Advertisers
  • Editors
  • Submit
    • Submit a Manuscript
    • Instructions for Authors
    • Journal Policies
  • Subscribe
    • Journal Subscriptions
    • Email Alerts
    • RSS Feeds
    • ImmunoCasts
  • More
    • Most Read
    • Most Cited
    • ImmunoCasts
    • AAI Disclaimer
    • Feedback
    • Help
    • Accessibility Statement
  • Follow The Journal of Immunology on Twitter
  • Follow The Journal of Immunology on RSS

Enhancement of Immunologically Induced Granule Exocytosis from Neutrophils by Cytochalasin B

Peter M. Henson and Zenaida G. Oades
J Immunol January 1, 1973, 110 (1) 290-293;
Peter M. Henson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zenaida G. Oades
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Polymorphonuclear neutrophil leukocytes (neutrophils) release granule enzymes to the extracellular medium after adherence to immune complexes or aggregates attached to surfaces too large to be phagocytosed (1–4). A number of facts have emerged in the past few years that define this phenomenon. The release has been shown to occur by direct exocytosis of granules along the neutrophil membrane in contact with the surface but not along the free, unattached membrane of the cell (2, 5). It requires stimulation by aggregated immunoglobulin G immune complexes, or complement on the surface, but not aggregated IgM, IgD, IgE or proteins unrelated to immunoglobulins (6). The release of granular enzymes requires calcium in the external medium and glycolytic metabolism on the part of the neutrophil. It is accompanied by stimulation of glucose oxidation by the hexose monophosphate pathway, but this is not required for the secretion. The release can be inhibited by diisopropyl fluorophosphate and agents which increase intracellular cyclic AMP (7, 8).

Footnotes

  • ↵1 The work was supported by United States Public Health Service Grant AI-07007, The American Heart Association and The Council for Tobacco Research; publication no. 589 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California.

  • Copyright, 1972, by The Williams & Wilkins Company
  • Copyright © 1973 by The American Association of Immunologists, Inc.

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

The Journal of Immunology
Vol. 110, Issue 1
1 Jan 1973
  • Table of Contents
  • Table of Contents (PDF)
  • Advertising (PDF)
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Immunology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Enhancement of Immunologically Induced Granule Exocytosis from Neutrophils by Cytochalasin B
(Your Name) has forwarded a page to you from The Journal of Immunology
(Your Name) thought you would like to see this page from the The Journal of Immunology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Enhancement of Immunologically Induced Granule Exocytosis from Neutrophils by Cytochalasin B
Peter M. Henson, Zenaida G. Oades
The Journal of Immunology January 1, 1973, 110 (1) 290-293;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Enhancement of Immunologically Induced Granule Exocytosis from Neutrophils by Cytochalasin B
Peter M. Henson, Zenaida G. Oades
The Journal of Immunology January 1, 1973, 110 (1) 290-293;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • The in Situ induction of tumoricidal activity in alveolar macrophages by liposomes containing muramyl depeptide is a thymus-independent process
  • A Cell Surface Antigen, TER, Expressed by Embryos and Germ Cells
  • A Monoclonal Antibody to Viral Glycoprotein Blocks Virus-Immune Effector T Cells Operating at H-2Dd but Not at H-2Kd
Show more COMMUNICATIONS

Similar Articles

Navigate

  • Home
  • Current Issue
  • Next in The JI
  • Archive
  • Brief Reviews
  • Pillars of Immunology
  • Translating Immunology

For Authors

  • Submit a Manuscript
  • Instructions for Authors
  • About the Journal
  • Journal Policies
  • Editors

General Information

  • Advertisers
  • Subscribers
  • Rights and Permissions
  • Accessibility Statement
  • FAR 889
  • Privacy Policy
  • Disclaimer

Journal Services

  • Email Alerts
  • RSS Feeds
  • ImmunoCasts
  • Twitter

Copyright © 2022 by The American Association of Immunologists, Inc.

Print ISSN 0022-1767        Online ISSN 1550-6606