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Selective Induction of Delayed Hypersensitivity by a Lipid Conjugated Protein Antigen Which Is Localized in Thymus Dependent Lymphoid Tissue

John Coon and Robert Hunter
J Immunol January 1, 1973, 110 (1) 183-190;
John Coon
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Robert Hunter
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Abstract

Multiple injections of bovine serum albumin (BSA) without adjuvant stimulate production of large amounts of antibody but no detectable delayed type hypersensitivity (DTH) in guinea pigs. In contrast, single or multiple injections of BSA heavily conjugated with a lipid, dodecanoic acid, without adjuvant, stimulated sustained DTH but no detectable antibody production. The DTH produced was specific for native BSA and no detectable immune response was produced against the fatty acid groups. This change in the type of immune response produced was associated with a change in the area of antigen localization in popliteal lymph nodes. Native BSA labeled with 125I was localized in germinal centers in the bone marrow derived cell area but was not detectable in the thymic dependent or thymus derived (T) cell area of the lymph nodes. In contrast, lipid conjugated BSA labeled with 125I was prominently localized in the thymic dependent area of the lymph nodes but was not found in the germinal centers of animals producing pure DTH reactions. These results suggest that the well known ability of lipids to enhance the production of DTH may be in part due to a lipid-mediated localization of antigen within the thymic dependent area of lymph nodes where it is in close association with many T type lymphocytes.

Footnotes

  • ↵1 Operated by the University of Chicago for the United States Atomic Energy Commission.

  • Received August 29, 1972.
  • Copyright, 1972, by The Williams & Wilkins Company
  • Copyright © 1973 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 110, Issue 1
1 Jan 1973
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Selective Induction of Delayed Hypersensitivity by a Lipid Conjugated Protein Antigen Which Is Localized in Thymus Dependent Lymphoid Tissue
John Coon, Robert Hunter
The Journal of Immunology January 1, 1973, 110 (1) 183-190;

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Selective Induction of Delayed Hypersensitivity by a Lipid Conjugated Protein Antigen Which Is Localized in Thymus Dependent Lymphoid Tissue
John Coon, Robert Hunter
The Journal of Immunology January 1, 1973, 110 (1) 183-190;
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Print ISSN 0022-1767        Online ISSN 1550-6606