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Surface Antigen Produced by Herpes Simplex Virus (HSV)

Michio Ito and Almen L. Barron
J Immunol March 1, 1972, 108 (3) 711-718;
Michio Ito
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Almen L. Barron
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Abstract

Surface antigen of cells infected with herpes simplex virus (HSV) was studied by mixed agglutination technique. The surface antigen was stable to heat at 56°C, formalin, periodate and 2-4-dinitrophenol, but was not detected after treatment with acetone or ethanol. Surface antigen preceded infectious virus and required protein synthesis. DNA synthesis was not required since cytosine arabinoside did not inhibit production of surface antigen. HSV surface antigen was not shared by other members of the herpesvirus group. Detection of surface antigen by mixed agglutination was distinguished from surface conditions responsible for adherence of sensitized sheep erythrocytes.

Footnotes

  • ↵1 Recipient of a Henry C. and Bertha H. Buswell Fellowship.

  • Received September 17, 1971.
  • Copyright © 1972 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 108, Issue 3
1 Mar 1972
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Surface Antigen Produced by Herpes Simplex Virus (HSV)
Michio Ito, Almen L. Barron
The Journal of Immunology March 1, 1972, 108 (3) 711-718;

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Surface Antigen Produced by Herpes Simplex Virus (HSV)
Michio Ito, Almen L. Barron
The Journal of Immunology March 1, 1972, 108 (3) 711-718;
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Print ISSN 0022-1767        Online ISSN 1550-6606