Abstract
The immunogenicity of two adenovirus structural proteins, hexon and fiber of adenovirus type 5, has been investigated. The lowest dose of antigen capable of inducing a primary immune response in guinea pigs was found to be 1 ng and 100 ng, respectively, for the two antigens. The immunogenicity of adenovirus antigens is discussed with respect to antigens from other microorganisms and vaccination with virus subunits.
Footnotes
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↵1 This work was partly supported by a grant from The Anna Fuller Foundation.
- Received July 29, 1971.
- Copyright, 1972, by The Williams & Wilkins Company
- Copyright © 1972 by The American Association of Immunologists, Inc.
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The Immunogenicity of Adenovirus Type 5 Structural Proteins
