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The Effect of Aging on Human Serum Immunoglobulin Concentrations

C. E. Buckley III and F. C. Dorsey
J Immunol October 1, 1970, 105 (4) 964-972;
C. E. Buckley III
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F. C. Dorsey
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Abstract

Single radial diffusion was used to measure the concentration of IgG, IgA and IgM in sera of 811 healthy individuals aged from birth to 92 years. Evaluation of age, race and sex differences was accomplished by multivariate analysis on loge transformed data using age as a linear covariate for each race-sex group within the 0 to 13, 14 to 27, 28 to 54 and 55 to 92 year age spans. Age contrasts between all groups were highly significant (p < 0.0001), while race and sex contrasts within all groups revealed only a significant difference in IgG related to race (p < 0.0133). Maximum serum immunoglobulin concentrations were reached in the third decade. Highly significant changes related to aging occur in older individuals as well as early in life. Average IgM concentrations decreased significantly by the sixth decade (p < 0.0005). Average IgG decreased significantly from the third through the sixth decade (p < 0.0027). Changes in serum IgA after maturity were small and not significant. These observations document the occurrence of a relative hypoglobulinemia in healthy older individuals.

Footnotes

  • ↵1 This work was supported by grants from the United States Public Health Service (AI-07499, 5-K3-AI-14797, HD-00668) and the American Medical Association (AMA-ERF).

  • Received March 30, 1970.
  • Copyright © 1970 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 105, Issue 4
1 Oct 1970
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The Effect of Aging on Human Serum Immunoglobulin Concentrations
C. E. Buckley, F. C. Dorsey
The Journal of Immunology October 1, 1970, 105 (4) 964-972;

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The Effect of Aging on Human Serum Immunoglobulin Concentrations
C. E. Buckley, F. C. Dorsey
The Journal of Immunology October 1, 1970, 105 (4) 964-972;
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Print ISSN 0022-1767        Online ISSN 1550-6606