Abstract
The production of agglutinating antibodies to the Ea-1a erythrocytic alloantigen in Mus musculus has previously been shown to be controlled by a single Mendelian recessive factor when strain YBR was crossed with BALB or CBA. It has now been determined that when YBR is crossed with C57BL/10, responsiveness is dominant and a strong nongenetic effect occurs. When positive assortative matings were made between YBR-B10 F2 segregants, a significant response to selection occurred, and estimates of the heritability of the response could be obtained. After one additional generation of selection the high responder line included 81% responders while the low responder line included no responders.
Footnotes
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↵2 This study was supported in part by a National Institutes of Health predoctoral genetics training grant, NIH-5-T01-GM-00071-12; in part by a National Institutes of Health postdoctoral fellowship, 1-F02-GM-33,294-01; and by NSF GB-7241.
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↵1 Parts of this study were taken from a thesis submitted to The Horace H. Rackham School of Graduate Studies in partial fulfillment of the requirements of the degree of Doctor of Philosophy.
- Received April 29, 1970.
- Copyright © 1970 by The American Association of Immunologists, Inc.
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