Abstract
Mice naturally infected transplacentally with lymphocytic choriomeningitis virus carry high titers of virus in their blood and tissues, make anti-viral antibody, and develop an associated chronic disease. The virus travels in the circulation in virus-IgG-complement(C) complexes. A study of the renal glomeruli of such transplacentally infected mice showed the presence of viral antigen, C3 and Ig at birth, and a progressive accumulation of virus-Ig complexes that led to death from glomerulonephritis in some mice by 2 weeks of age.
Footnotes
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↵2 Recipient of Career Development Award I KO4-A1 42580 AID from the United States Public Health Service.
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↵1 This is publication 413 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This research was supported by United States Public Health Service Grants AI-09484 and AI-07007.
- Received May 13, 1970.
- Copyright © 1970 by The American Association of Immunologists, Inc.
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