Abstract
Peromyscus 7Sγ1- and 7Sγ2-globulins which contained antibody to hen egg albumin (HEA) were isolated, quantitated, and tested for their ability to mediate passive cutaneous anaphylaxis (PCA) and to fix complement. Peromyscus antibody of the 7Sγ2 class induced a PCA reaction in guinea pigs with as little as 4.9 ABC units of antibody/milliliter. With 40 times as much 7Sγ1 antibody, however, no PCA reaction was produced in guinea pigs. In contrast, only Peromyscus 7Sγ1 anti-HEA induced the PCA reaction in Peromyscus. Complement fixation and hemolysis of HEA-conjugated erythrocytes were found only with antibodies of the 7Sγ2 class.
- Received February 20, 1970.
- Copyright © 1970 by The American Association of Immunologists, Inc.
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