Table I. RCAN1-deficient mice display enhanced early inflammatory cytokine production
Uninfecteda4 hb24 hc
RCAN1+/+RCAN1−/−RCAN1+/+RCAN1−/−RCAN1+/+RCAN1−/−
Lung
 IL-693.7 ± 44.463 ± 25.6117.8 ± 17.4***523.6 ± 60.0***2753.4 ± 701.42492.6 ± 1018.1
 IL-1βN.D.N.D.1793.9 ± 201.6***3611.9 ± 289.0***6348.7 ± 244.6*7581.4 ± 262.3*
 TNF17.1 ± 2.419.5 ± 3.189.6 ± 4.4**208.8 ± 30.2**138.7 ± 25.0*214.5 ± 23.3*
 MIP-224.7 ± 7.466.9 ± 2.41912.1 ± 207.9***3143.2 ± 231.8***4313.9 ± 489.44207.6 ± 294.0
 LIX197.8 ± 86.2498.1 ± 196.61135.3 ± 55.0**1361.0 ± 15.2**5304.8 ± 490.15390.8 ± 428.7
 KC318.2 ± 116.3819.5 ± 207.36811.5 ± 329.8**8166.0 ± 91.4**7502.2 ± 282.67687.3 ± 97.5
 TGF-β241.2 ± 99.9379.2 ± 57.6350.3 ± 35.2*248.4 ± 13.2*259.3 ± 26.6234.1 ± 18.6
BALF
 IL-657.4 ± 4.564.1 ± 8.6330.8 ± 81.0**961.0 ± 115.0**6523.5 ± 2107.63658.3 ± 1267.6
 IL-1βN.D.N.D.134.3 ± 3.1*192.8 ± 21.0*147.1 ± 50.4377.7 ± 98.0
 TNF19.9 ± 1.2*32.4 ± 2.9*502.3 ± 35.3***1002.2 ± 67.5***819.5 ± 97.8854.2 ± 73.9
 MIP-249.4 ± 18.091.9 ± 36.42475.5 ± 467.3**4961.8 ± 119.4**5493.1 ± 337.05728.6 ± 92.0
 LIX191.3 ± 102.477.8 ± 24.4402.7 ± 136.3*1198.8 ± 285.5*1018.6 ± 252.6*3517.0 ± 265.9*
 KC14.4 ± 7.5*87.8 ± 16.0*6454.8 ± 348.7*7637.2 ± 119.4*4315.7 ± 729.7*6701.2 ± 757.1*
 TGF-βN.D.30.0 ± 18.1139.2 ± 28.2*42.6 ± 28.1*50.7 ± 17.2***210.4 ± 16.5***
  • a Data are the mean ± SE of 4 mice per group (pg/ml).

  • b Data are the mean ± SE of 6 mice per group (pg/ml).

  • c Data are the mean ± SE of 10 mice per group (pg/ml).

  • * p < 0.05, **p < 0.01, ***p < 0.001.

  • N.D., Not detected.