Table II. Differentially regulated inflammatory pathway genes in kidneys from chronically hypoxic mice
GeneDescriptionEntrez Gene IDFold Induction
IghgIg H chain (γ polypeptide)BC092269−5.5
Cxcl9Chemokine (C-X-C motif) ligand 9NM_008599−3.5
Cxcl10Chemokine (C-X-C motif) ligand 10NM_021274−2.9
Ccl2Chemokine (C-C motif) ligand 2NM_011333−2.5
Ccr2Chemokine (C-C motif) receptor 2NM_020008−2.4
Cxcr3Chemokine (C-X-C motif) receptor 3NM_009910−2.1
Clec7aC-type lectin domain family 7, member aNM_020008−2.0
C2taClass II transactivatorNM_007575−1.9
C8aComplement component 8, α polypeptideNM_146148−1.9
LtbLymphotoxin BNM_008518−1.9
Serpinf2Serine (or cysteine) peptidase inhibitor, clade F, member 2NM_008878−1.9
Cd74CD74 antigenNM_001042605−1.9
Ly86Lymphocyte Ag 86NM_010745−1.8
Mbl1Mannose binding lectin (A)NM_010775−1.8
PrlrProlactin receptorNM_011169−1.8
Ccl7Chemokine (C-C motif) ligand 7NM_013654−1.7
Fn1Fibronectin 1NM_010233−1.7
Il16IL-16NM_010551−1.7
Cxcr6Chemokine (C-X-C motif) receptor 6NM_030712−1.7
Il10raIL-10RαNM_008348−1.7
Il1bIL-1βNM_008361−1.6
Tlr2TLR2NM_011905−1.6
CalcaCalcitonin/calcitonin-related polypeptide, αNM_001033954−1.6
Cd44CD44 antigenNM_009851−1.6
Blr1Burkitt/lymphoma receptor 1NM_007551−1.6
Il2rbIL-2R, β-chainNM_008368−1.6
Ccr5Chemokine (C-C motif) receptor 5NM_009917−1.5
Masp2Mannan-binding lectin serine peptidase 2NM_010767−1.5
C1qaComplement component 1, q subcomponent, α polypeptideNM_007572−1.5
Il2rgIL-2R, γ-chainNM_013563−1.5
Cmtm3CKLF-like MARVEL transmembrane domain containing 3NM_024217−1.5
OsmrOncostatin M receptorNM_0110191.5
Csf2rb2CSF2R, β2NM_0077811.6
Cxcl4Chemokine (C-X-C motif) ligand 4NM_0199321.6
Chi3l4Chitinase 3-like 4NM_1451261.7
Il17rbIL-17R BAF2081091.8
CfdComplement factor D (adipsin)NM_0134591.9
Cd163CD163 antigenNM_0530941.9
Cxcl7Chemokine (C-X-C motif) ligand 7NM_0237852.1
Serpina1bSerine (or cysteine) peptidase inhibitor, clade A, member 1bBC0370082.2
HcHemolytic complementNM_0104062.7
Ccbp2Chemokine binding protein 2NM_0216092.8
Grem2Gremlin 2 homolog, cysteine knot superfamilyNM_0118253.5
Ahsgα2-HS-glycoproteinNM_0134654.2
Chi3l3Chitinase 3-like 3NM_0098926.4
  • Relative expression levels of genes assigned to inflammatory pathways that were at least ≥1.5-fold upregulated or downregulated and had <10% false discovery rate (total of 1170 probes and 912 genes) in kidneys from mice with mutated β-hemoglobin (Hbbth3/th3) compared to wild type littermates. Inflammatory pathway genes were considered those genes with ontologies of inflammatory response, activation of plasma proteins involved in acute inflammatory response, cytokine activity, and chemokine activity (http://david.abcc.ncifcrf.gov/).