Table I. Phenotypic comparison of CD56bright and CD56dim NK cells
MarkerAlso Known AsCD56brightCD56dim
CD56NCAM-1+++
CD16FcγRIIIa±++
Inhibitory receptors
 Inhibitory KIR (2DL, 3DL)CD158a, b1, b2, e1±
 Activating KIR (2DS, 3DS)CD158e2, h, j±
 2DL4CD158d+
 ILT2CD85j±
 CD94/NKG2A++±
Activating receptors
 NKp30NCR3 or CD337+++
 NKp46NCR1 or CD335+++
 DNAM-1CD226+++
Cytokine receptors
 IL-2RαCD25+
 IL-2RβCD122+++
 IL-1R1IL1RA+++
 IL-18R1IL18RA or CD218a+++
Chemokine receptors
 CCR7CD197++
 CXCR3CD183++±
 CXCR1IL8RA or CD181++
 CX3CR1GPR13++
Adhesion molecules
 CD2LFA-2++±
 CD44HCAM+++
 CD49eα5 integrin, ITGA5+++
 CD54ICAM-1++±
 CD62LL-selectin++±
 CD11aITGAL or LFA-1+++
 CD11bITGAM or MAC-1++
 CD11cITGAX++±
Other molecules
 CD57HNK1 or LEU7±
 CD160++
 CD55DAF+++
 CD59MAC-IP+++
 HLA-DR+
 CD6+
 CD161KLRB1++±
 CD159cNKG2C±
 CD117c-kit++
Molecules needed for cytolytic function
 Perforin+++
 Granzyme A+++
 Granzyme B++
 Granzyme M++
 Granzyme K++
  • ++, strong expression (bright); +, weak expression (dim); ±, expression only on a subpopulation; -, no expression.