Table II.

Comparison of M1 genes expressed in HCMV-infected monocytes/macrophagesa

Category and Full Gene NameGene TitleProbe SetFold Change
Membrane receptors
 Interleukin 15 receptor, alphaIL15RA41677_at15.3
 Chemokine (C-C motif) receptor 7CCR71097_s_at3.0
 Interleukin 2 receptor, gamma (severe combined immunodeficiency)IL2RG1506_at1.9
 Interleukin 7 receptorIL7R1370_at1.7
Cytokine and chemokines
 Interleukin 6 (interferon, beta 2)IL638299_at280.8
 Chemokine (C-X-C motif) ligand 10CXCL10431_at69.3
 Interleukin 12BIL12B563_at33.7
 Chemokine (C-C motif) ligand 20CCL2040385_at16.5
 Chemokine (C-X-C motif) ligand 11CXCL1135061_at15.2
 Tumor necrosis factor (TNF superfamily, member 2)TNF1852_at14.6
 Tumor necrosis factor (ligand) superfamily, member 10TNFSF101715_at5.8
 Interleukin 15IL151036_at4.0
 Pre-B-cell colony-enhancing factor 1PBEF133849_at1.9
 Chemokine (C-C motif) ligand 5CCL51403_s_at1.6
 Endothelial cell growth factor 1 (platelet-derived)ECGF136879_at−1.8
 Chemokine (C-C motif) ligand 19CCL1936067_atnc
 Chemokine (C-X-C motif) ligand 9CXCL937219_atnc
 Chemokine (C-C motif) ligand 15CCL1533789_atnc
Apoptosis-related genes
 BCL2-related protein A1BCL2A12002_s_at4.9
 XIAP associated factor-1HSXIAPAF135583_at3.4
 Tumor necrosis factor receptor superfamily, member 6TNFRSF61440_s_at3.1
 Baculoviral IAP repeat-containing 3BIRC31717_s_at2.5
 Growth arrest and DNA-damage-inducible, alphaGADD45A1911_s_at2.1
Solute carriers
 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5SLC7A532186_at1.6
 Solute carrier family 31 (copper transporters), member 2SLC31A234749_atnc
Enzymes
 Adenylate kinase 3AK332331_at9.3
 Indoleamine-pyrrole 2,3-dioxygenaseINDO36804_at4.1
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3PFKFB337111_g_at3.6
 2′,5′-oligoadenylate synthetase 2, 69/71 kDaOAS239263_at3.4
 Proteasome (prosome, macropain) activator subunit 2 (PA28 beta)PSME21184_at1.8
 Proteasome (prosome, macropain) subunit, beta type, 9PSMB938287_at1.7
 2′,5′-oligoadenylate synthetase-likeOASL269_atnc
 Chitinase 3-like 1 (cartilage glycoprotein-39)CHI3L136197_atnc
 Hydroxysteroid (11-beta) dehydrogenase 1HSD11B135702_atnc
 Phosphofructokinase, plateletPFKP39175_atnc
 Proteasome (prosome, macropain) subunit, alpha type, 2PSMA241240_atnc
Extracellular matrix
 Pentaxin-related gene, rapidly induced by IL-1 betaPTX31491_at13.5
 Inhibin, beta A (activin A, activin AB alpha polypeptide)INHBA40357_at9.9
 Chondroitin sulfate proteoglycan 2 (versican)CSPG231682_s_at−14.4
 Insulin-like growth factor binding protein 4IGFBP41737_s_atnc
 Apolipoprotein L, 1APOL135099_atnc
 Platelet-derived growth factor alpha polypeptidePDGFA1109_s_atnc
DNA-binding factors
 Interferon regulatory factor 1IRF1669_s_at3.3
 Interferon regulatory factor 7IRF736412_s_at2.1
 Homeo box (expressed in ES cells) 1HESX135463_atnc
 Activating transcription factor 3ATF3287_atnc
  • a Examined M1 genes are based on the transcriptional profiling work of Martinez et al. (47 ). nc, No change.