Table I.

Inα 215-234-induced biphasic EAO with early increased fertility and delayed POF

ImmunogenTotal Females MatedNumber of Mice Producing LittersTotal Offspring for All LittersMean Litter Size (± SD)Mean Litter Weight (± SD)Mean Birth Weight (± SD)
Mating 7–9 weeks after immunization
 Inα 215-23488/89511.88 ± 0.8115.23 ± 0.821.30 ± 0.04
 CFA87/8568.00 ± 0.5811.05 ± 0.771.39 ± 0.02
p = 0.003p = 0.003p = 0.10
Mating 43–45 weeks after immunization
 Inα 215-23474/7123.0 ± 0.814.58 ± 1.231.51 ± 0.00
 CFA88/8516.37 ± 0.189.5 ± 0.351.49 ± 0.03
p = 0.0002p = 0.0004p = 0.76