Table II.

Genes within the confidence interval of Eae5

GeneabPosition in RatPossible Role in EAE
D12Rat51 22417925–22418145 bp (22.4 Mb)
NSUN5 22439343–22444280 bp (22.4 Mb)
Tri50 22446134–22461108 bp (22.4 Mb)
FKBP6 22464623–22476654 bp (22.5 Mb)Neuron survival and growth
Fzd9 22572493–22574271 bp (22.6 Mb)
BAZ1B 22578825–22597102 bp (22.6 Mb)Transcription factor
CLDN4 22687188–22687820 bp (22.7 Mb)Tight junction protein, brain-blood barrier
WBSCR27 22693188–22701632 bp (22.7 Mb)
WBSCR28 22730401–22734942 bp (22.7 Mb)
Eln 22892483–22935863 bp (22.9 Mb)
Limk1 22952110–22984673 bp (23.0 Mb)CNS development
WBSCR1 23008919–23023902 bp (23.0 Mb)Translation initiation factor
Wbscr5 23035111–23041465 bp (23.0 Mb)
RFC2 23046412–23059175 bp (23.0 Mb)
No descriptionc23072490–23073180 bp (23.1 Mb)
No descriptionc23081041–23082885 bp (23.1 Mb)
Cyln2 23088867–23152664 bp (23.1 Mb)
GTF2IRD1 23181243–23289310 bp (23.2 Mb)
D12Got46 23225514–23225729 bp (23.2 Mb)
GTF2I 23350479–23408833 bp (23.4 Mb)JAK in B cell signaling
Ncf-1 23441313–23449099 bp (23.4 Mb)Subunit of NADPH oxidase complex
GTF2IRD2 23513696–23545170 bp (23.5 Mb)
WBSCR16 23560961–23590301 bp (23.6 Mb)
GATS 23600395–23637029 bp (23.6 Mb)
D12Rat26 23708771–23708949 bp (23.7 Mb)
D12Rat8 23797947–23798087 bp (23.8 Mb)
D12Rat9 24333613–24333738 bp (24.3 Mb)
  • a Genes confirmed in rat are written with a first capital letter and remaining letters in lowercase. Genes not confirmed, but with human and/or mouse orthologs, are written with capital letters. Microsattelite markers used within this region are indicated with bold letters and included at their respective positions. Data is retrieved from Ensembl version 29 (www.ensembl.org/Rattus_norvegicus/index.html.

  • b All genes are within the chromosomal location 12q12 in rat and 7q11.23 in human (Ensembl).

  • c Genes with no description were not analyzed.