Table II.

Relationship among virus levels, cell numbers, and activitya

HCVHCV-HIVHCV-HIV Slow ProgressorsHIVHealthy ControlAll HCV-Infected SubjectsAll HIV-Infected Subjects
MDC vs PDC freqr = 0.54r = 0.54r = 0.63r = 0.91r = 0.67r = 0.68r = 0.75
p = 0.02p = 0.02p = 0.04 p < 0.001 p = 0.02 p < 0.001 p < 0.001
CD4 count vs MDC freqNDr = 0.33r = 0.8r = 0.38NDNDr = 0.65
p = 0.12p = 0.05p = 0.10p < 0.001
CD4 count vs PDC freqNDr = −0.07r = 0.60r = 0.18NDNDr = 0.32
p = 0.40p = 0.14p = 0.28p = 0.04
HCV log vs IC IFN-αr = −0.31r = −0.44r = −0.14NDNDr = −0.41ND
p = 0.14p = 0.10p = 0.39p = 0.03
HIV log vs IC IFN-αNDr = 0.024r = 0.22r = −0.50NDNDr = −0.25
p = 0.96p = 0.71p = 0.04p = 0.02
HIV log vs IC IL-12NDr = −0.27r = −0.056r = −0.45NDNDr = −0.53
p = 0.73p = 0.94p = 0.07p = 0.004
IC IFN-α vs CpG IFN-αr = 0.18r = −0.07r = 0.29r = −0.01r = 0.79NDND
p = 0.27p = 0.41p = 0.19p = 0.48p = 0.002
IC IFN-α vs MDC freqr = 0.45r = −0.07r = 0.08r = 0.07r = 0.21r = 0.39r = −0.11
p = 0.07p = 0.40p = 0.49p = 0.42p = 0.74p = 0.03p = 0.79
IC IFN-α vs IC IL-12r = −0.75r = 0.53r = 0.43r = 0.46r = −0.68r = 0.46r = 0.57
p = 0.04p = 0.11p = 0.19p = 0.06p = 0.04p = 0.03p = 0.001
IC IL-12 vs cumulative HCVr = 0.9r = −0.87r = 0.41NDNDr = 0.18ND
 protein Ag-specific T cell freqp = 0.02p = 0.16p = 0.21p = 0.27
  • a ND, not done; freq, frequency; p < 0.05 correlations are represented in bold.