Table II.

Changes in smooth muscle contractility in response to substance P in the presence and the absence of TTX in WT BALB/c mice treated with IL-4C or IL-13 for 7 days or infected with H. polygyrus or N. brasiliensisa

Substance PSubstance P + TTX
WT vehicle11,589 ± 1,0178,963 ± 852
WT IL-411,940 ± 1,68813,213 ± 1,143
WT IL-1320,743 ± 1,212b13,842 ± 1,815c
WT H. polygyrus7,646 ± 1,0216,791 ± 1,227
WT N. brasiliensis18,800 ± 1,497b9,183 ± 3,050c
  • a Values are the mean ± SEM expressed in milli-Newtons per square centimeter. Substance P, 1 μM. n = 6–8.

  • b p < 0.01 vs WT vehicle.

  • c p < 0.05 vs agonist alone.