Table I.

Changes in smooth muscle contractility in response to acetylcholine in the presence and the absence of TTX in WT BALB/c mice treated with IL-4C or IL-13 for 7 days or infected with H. polygyrus or N. brasiliensisa

ACHACH + TTX
WT vehicle7,675 ± 1,2287,221 ± 624
WT IL-49,301 ± 9118,430 ± 387
WT IL-1313,291 ± 1,324b5,413 ± 1,719c
WT H. polygyrus26,928 ± 1,838d22,182 ± 1,915
WT N. brasiliensis29,635 ± 4,163d13,274 ± 3,267c
  • a Values are the mean ± SEM expressed in milli-Newtons per square centimeter to Acetylcholine (ACH), 1 mM. n = 4–6.

  • b p < 0.05 vs WT vehicle.

  • c p < 0.05 vs agonist alone.

  • d p < 0.01 vs WT vehicle.