Table 3A.


MoleculeMolecule SizeCell TypesCommentsRefs.
Identified via gene cloning
B cell maturation factor (BCMA)184 aaB cellsTNFR family member; receptor for TALL-1 and APRILMadry et al., Int. Immunol. 1998; 10:1693. Shu H. B. and Johnson H., Proc. Natl. Acad. Sci. USA 2000; 97:9156.
B7-H2302 aaDendritic cellsNew member of B7 family; binds ICOS on activated T cellsWang S. et al., Blood 2000; 96:2808.
CLEC-1280 aaDendritic cellsNovel C-type lectin-like receptor with cytoplasmic tyrosine-based motifColonna M. et al., Eur. J. Immunol. 2000; 30:697.
CMRF-35A224 aaNK cells, neutrophils, monocytes, dendritic cells and subset of T lymphocytesNovel Ig superfamily receptors. CMRF-35H contains 3 cytoplasmic tyrosine based motifsJackson et al., Eur. J. Immunol. 1992; 22:1157.
CMRF-35H300 aaGreen et al., Int. Immunol. 1998; 10:891.
CS1NK cellsNovel receptor belonging to CD2 subset of Ig superfamilyBoles K. S. et al., Immunogenetics 2001; 52:302.
DC-STAMP470 aaDendritic cellsNovel protein containing seven putative transmembrane domains.Hartgers F. C. et al., Eur. J. Immunol. 2000; 30:3585.
EMR3652 aaMainly leukocyte restricted; highest levels on neutrophils, monocytes and macrophagesNovel EGF-TM7 molecule. Interacts with a surface ligand on myeloid cells.Stacey M. et al., J. Biol. Chem. 2001; 276:18863.
Flt-1 (VEGFR-1)Endothelial cells, monocytesSawano A. et al., Blood 2001; 97:785.
GPRv53390 aaLeukocytesIdentified by gene cloning; G-protein-coupled histamine receptorOda T. et al., J. Biol. Chem. 2000; 275:36781.
IRTA1 and IRTA2Subpopulations of B cellsHomologous to the Fc and inhibitory receptor familiesHatzivassiliou G. et al., Immunity 2001; 14:277.
M1601453 aaMacrophagesNew member of scavenger receptor cysteine-rich superfamilyGronlund J. et al., J. Immunol. 2000; 165:6406.
MARCO (macrophage receptor with collagenous structure)520 aaMacrophagesClass A scavenger receptor; involved in bacterial clearance in vivoElomaa et al., J. Biol. Chem. 1998; 273:4530. Van der Laan L. J. et al., J. Immunol. 1999; 162:939.
TACI293 aaB cellsTNFR family member. Receptor for TALL-1 and APRILXia X. Z. et al., J. Exp. Med. 2000; 192:137.
TREM-1 and TREM-2 (triggering receptors expressed on myeloid cells)Neutrophils and subset of monocytes (TREM-1) and macrophages (TREM-2)Novel Ig superfamily receptors. TREM-1 triggers neutrophil secretion (e.g. IL-8) and degranulation; TREM-2 activates macrophages; both associate with DAP12.Bouchon A. et al., J. Immunol. 2000; 164:4991. Daws M. R. et al., Eur. J. Immunol. 2001; 31:783.