Table I.

Response of GM-CSF +/+, +/−, and −/− mice to CIA

ParameterGM-CSF Genotype\E
+/++/−−/−
Clinical assessmenta \E
Average clinical score (d22-60)b3.4 ± 1.02.1 ± 0.50.1 ± 0.1e
Severity median (range)c9 (1–12)6 (2–12)2 (1–2)
Anti-CII IgG (mg/ml)d1.60 ± 0.322.04 ± 0.351.71 ± 0.29
  • a Summary of data in Figure 1.

  • b Values show mean ± SEM of the clinical scores of individual mice averaged over days 22 to 60.

  • c Values show arthritis severity as the median (and range) of maximum clinical scores obtained for the responsive mice of each genotype.

  • d Values are mean ± SEM concentrations of anti-CII total IgG in the mouse sera at day 60.

  • e p < 0.005 and p < 0.001, compared to GM-CSF+/+ and GM-CSF+/− groups, respectively.