Table III.

Comparison of recognition of Ac1–9 position 6 APL by different Ac1–9-specific T cell populationsa

Residue at Position 6Ac1–9-Specific T Cell Population
Tg4.TCLPolyclonal TCLMBP TCR1 T cells
Ala++++++
Arg+++
Asn+
Asp
Cys++
Glu
Gln+++
GlyAntagonist++++++
His+++
IleAntagonist++++
LeuAntagonist+
Lys+
Met++
Phe+
ProAgonist++++++
Ser++++
ThrAntagonist++++
Trp+
Tyr++
ValAgonist/antagonistb+++
  • a The response patterns of Tg4 T cells, polyclonal TCL, and MBP TCR1 transgenic T cells to position 6 Ac1–9 APL are shown. In each column, + and − represent the presence or absence of agonist activity, respectively. The position 6 APL with Tyr at position 4, which acted as antagonists of the Tg4.TCL, are also shown.

  • b The Val6 APL with Tyr at position 4 behaved as an antagonist of Tg4.TCL at low concentrations, but was stimulatory at high concentrations. The Val6, Lys4 APL did not stimulate Tg4.TCL.