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Future Table of Contents: Volume 176 / No. 3 / Feb 1 2006

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

IN THIS ISSUE

PILLARS OF IMMUNOLOGY

In the Beginning was Sm

George C. Tsokos

Pillars Article: Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus. J. Immunol. 1966. 96: 464-471.

E. M. Tan and H. G. Kunkel

BRIEF REVIEWS

The Central Role of the Alternative Complement Pathway in Human Fn1Disease

Joshua M. Thurman and V. Michael Holers

Experimental Models to Study Development and Function of the Human Immune System In Vivo

Nicolas Legrand, Kees Weijer, and Hergen Spits

CUTTING EDGE

Cutting Edge: An Alternative Pathway of CD4+ T Cell Differentiation Is Induced Following Activation in the Absence of -Chain-Dependent Cytokine Signals

Shane R. Mayack and Leslie J. Berg

Cutting Edge: Identification of E-Cadherin as a Ligand for the Murine Killer Cell Lectin-Like Receptor G1

Carsten Grundemann, Monika Bauer, Oliver Schweier, Nanette von Oppen, Ute Lassing, Philippe Saudan, Karl-Friedrich Becker, Klaus Karp, Thomas Hanke, Martin F. Bachmann, and Hanspeter Pircher

Cutting Edge: Deficiency in the E3 Ubiquitin Ligase Cbl-b Results in a Multifunctional Defect in T cell TGF- Sensitivity in Vitro and in Vivo

Elizabeth A. Wohlfert, Leonid Gorelik, Robert Mittler, Richard A. Flavell, and Robert B. Clark

Cutting Edge: A Novel Nonoxidative Phagosomal Mechanism Exerted by Cathepsin-D Controls Listeria monocytogenes Intracellular Growth

Elida del Cerro-Vadillo, Fidel Madrazo-Toca, Eugenio Carrasco-Marin, Lorena Fernandez-Prieto, Christian Beck, Francisco Leyva-Cobin, Paul Saftig, and Carmen Alvarez-Dominguez

Cutting Edge: Prostaglandin D2 Enhances Leukotriene C4 Synthesis by Eosinophils during Allergic Inflammation: Synergistic In Vivo Role of Endogenous Eotaxin

Fabio P. Mesquita-Santos, Adriana Vieira-de-Abreu, Andrea S. Calheiros, Isabela H. Figueiredo, Hugo C. Castro-Faria-Neto, Peter F. Weller, Patricia T. Bozza, Bruno L. Diaz, and Christianne Bandeira-Melo

Cutting Edge: Novel Human Dendritic Cell- and Monocyte-Attracting Chemokine-like Protein Identified by Fold Recognition Methods

M. Teresa Pisabarro, Beatrice Leung, Mandy Kwong, Racquel Corpuz, Gretchen D. Frantz, Nancy Chiang, Richard Vandlen, Lauri J. Diehl, Nicholas Skelton, Hok Seon Kim, Dan Eaton, and Kerstin N. Schmidt

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Soluble HLA-G Inhibits Cell Cycle Progression in Human Alloreactive T Lymphocytes

Rajia Bahri, Francois Hirsch, Adeline Josse, Nathalie Rouas-Freiss, Nicolas Bidere, Aime Vasquez, Edgardo D. Carosella, Bernard Charpentier, and Antoine Durrbach

CD11b+/Gr-1+ Myeloid Suppressor Cells Cause T Cell Dysfunction after Traumatic Stress

Valeriya P. Makarenkova, Vishal Bansal, Benjamin M. Matta, Lori Ann Perez, and Juan B. Ochoa

The Endoplasmic Reticulum Is a Key Component of the Plasma Cell Death Pathway

Nadege Pelletier, Montserrat Casamayor-Palleja, Karelle De Luca, Paul Mondiere, Frederic Saltel, Pierre Jurdic, Chantal Bella, Laurent Genestier, and Thierry Defrance

Direct Costimulatory Effect of TLR3 Ligand Poly(I:C) on Human T Lymphocytes

Daniela Wesch, Susann Beetz, Hans-Heinrich Oberg, Matthias Marget, Kirsten Krengel, and Dieter Kabelitz

Flightless I Homolog Negatively Modulates the TLR Pathway

Tianyi Wang, Tsung-Hsien Chuang, Tapani Ronni, Sheng Gu, Yu-Chun Du, Hong Cai, Hui-Qiao Sun, Helen L. Yin, and Xian Chen

Immunologic Control of Tumors by In Vivo Fc Receptor-Targeted Antigen Loading in Conjunction with Double-Stranded RNA-Mediated Immune Modulation

Adrian Bot, Dan Smith, Bill Phillips, Simona Bot, Constantin Bona, and Habib Zaghouani

Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function

Cunren Liu, Shaohua Yu, Kurt Zinn, Jianhua Wang, Liming Zhang, Yujiang Jia, John C. Kappes, Stephen Barnes, Robert P. Kimberly, William E. Grizzle, and Huang-Ge Zhang

Potentiation of Antigen-Stimulated V9V2 T Cell Cytokine Production by Immature Dendritic Cells (DC) and Reciprocal Effect on DC Maturation

Marie-Claire Devilder, Sophie Maillet, Isabelle Bouyge-Moreau, Emmanuel Donnadieu, Marc Bonneville, and Emmanuel Scotet

Critical, but Conditional, Role of Ox40 in Memory T Cell-Mediated Rejection

Minh Diem Vu, Michael R. Clarkson, Hideo Yagita, Laurence A. Turka, Mohamed H. Sayegh, and Xian Chang Li

CD40 Expression by Microglial Cells Is Required for Their Completion of a Two-Step Activation Process During Central Nervous System Autoimmune Inflammation

Eugene D. Ponomarev, Leah P. Shriver, and Bonnie N. Dittel

Soluble Form of T Cell Ig Mucin 3 Is an Inhibitory Molecule in T Cell-Mediated Immune Response

Hui Geng, Gui-Mei Zhang, Dong Li, Hui Zhang, Ye Yuan, Han-Gang Zhu, Han Xiao, Ling-Fei Han, and Zuo-Hua Feng

A Cell-Type Specific CD1d Expression Program Modulates Invariant NKT Cell Development and Function

Michael I. Zimmer, Angela Colmone, Kyrie Felio, Honglin Xu, Averil Ma, and Chyung-Ru Wang

Protein Expression of TNF- in Psoriatic Skin Is Regulated at a Posttranscriptional Level by MAPK-Activated Protein Kinase 2

Claus Johansen, Anne Toftegaard Funding, Kristian Otkjaer, Knud Kragballe, Uffe Birk Jensen, Mogens Madsen, Lise Binderup, Tine Skak-Nielsen, Marianne Scheel Fjording, and Lars Iversen

Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and T Cell Factor (TCF) 7 (TCF-1) following Antigen Encounter In Vitro and In Vivo

Tim Willinger, Tom Freeman, Mark Herbert, Hitoshi Hasegawa, Andrew J. McMichael, and Margaret F. C. Callan

Tumor-Specific CD4+ T Cells Are Activated by Cross-Dressed Dendritic Cells Presenting Peptide-MHC Class II Complexes Acquired from Cell-Based Cancer Vaccines

Brian P. Dolan, Kenneth D. Gibbs, Jr., and Suzanne Ostrand-Rosenberg

CXCR3/CXCR3 Ligand Biological Axis Impairs RENCA Tumor Growth by a Mechanism of Immunoangiostasis

Judong Pan, Marie D. Burdick, John A. Belperio, Ying Ying Xue, Craig Gerard, Sherven Sharma, Steven M. Dubinett, and Robert M. Strieter

Protein Vaccines Induce Uncommitted IL-2-Secreting Human and Mouse CD4 T Cells, Whereas Infections Induce More IFN--Secreting Cells

Anagha A. Divekar, Dietmar M. W. Zaiss, F. EunHyung Lee, Dacheng Liu, David J. Topham, Alice J. A. M. Sijts, and Tim R. Mosmann

Enhanced FTY720-Mediated Lymphocyte Homing Requires Gi Signaling and Depends on 2 and 7 Integrin

Oliver Pabst, Heike Herbrand, Stefanie Willenzon, Tim Worbs, Angela Schippers, Werner Muller, Gunter Bernhardt, and Reinhold Forster

Splenic Dendritic Cells Induced by Oral Antigen Administration Are Important for the Transfer of Oral Tolerance in an Experimental Model of Asthma

Katsuya Nagatani, Makoto Dohi, Yasuo To, Ryoichi Tanaka, Katsuhide Okunishi, Kazuyuki Nakagome, Kayo Sagawa, Yudo Tanno, Yoshinori Komagata, and Kazuhiko Yamamoto

The JNK Are Important for Development and Survival of Macrophages

S. Roy Himes, David P. Sester, Timothy Ravasi, Stephen L. Cronau, Tedjo Sasmono, and David A. Hume

IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells

Steven J. Burgess, Alina I. Marusina, Ishani Pathmanathan, Francisco Borrego, and John E. Coligan

CD8 T cells, Like CD4 T cells, Are Triggered by Multivalent Engagement of TCRs MHC-Peptide Ligands but Not by Monovalent Engagement

Jennifer D. Stone and Lawrence J. Stern

Expansion of Functionally Immature Transitional B Cells Is Associated with Human-Immunodeficient States Characterized by Impaired Humoral Immunity

Amanda K. Cuss, Danielle T. Avery, Jennifer L. Cannons, Li Jun Yu, Kim E. Nichols, Peter J. Shaw, and Stuart G. Tangye

CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity

Yoshihiro Hayakawa and Mark J. Smyth

Therapeutic Vaccination of Active Arthritis with a Glycosylated Collagen Type II Peptide in Complex with MHC Class II Molecules

Balik Dzhambazov, Kutty Selva Nandakumar, Jan Kihlberg, Lars Fugger, Rikard Holmdahl, and Mikael Vestberg

Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling

Douglas D. Taylor, Sibel Akyol, and Cicek Gercel-Taylor

Human and Thymocyte Development: TCR Gene Rearrangements, Intracellular TCR Expression, and Developmental Potential--Differences between Men and Mice

Michelle L. Joachims, Jennifer L. Chain, Scott W. Hooker, Christopher J. Knott-Craig, and Linda F. Thompson

Responsiveness of Naive CD4 T Cells to Polarizing Cytokine Determines the Ratio of Th1 and Th2 Cell Differentiation

Natallia Mikhalkevich, Brian Becknell, Michael A. Caligiuri, Micheal D. Bates, Richard Harvey, and Wei-ping Zheng

TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts

Thomas B. Thornley, Michael A. Brehm, Thomas G. Markees, Leonard D. Shultz, John P. Mordes, Raymond M. Welsh, Aldo A. Rossini, and Dale L. Greiner

Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help

Luana O. Atherly, Michael A. Brehm, Raymond M. Welsh, and Leslie J. Berg

CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer

Mark J. Smyth, Michele W. L. Teng, Jeremy Swann, Konstantinos Kyparissoudis, Dale I. Godfrey, and Yoshihiro Hayakawa

Brain-Derived Heat Shock Protein 70-Peptide Complexes Induce NK Cell-Dependent Tolerance to Experimental Autoimmune Encephalomyelitis

Grazyna Galazka, Mariusz Stasiolek, Agata Walczak, Anna Jurewicz, Alicja Zylicz, Celia F. Brosnan, Cedric S. Raine, and Krzysztof Selmaj

Respiratory Syncytial Virus G Protein and G Protein CX3C Motif Adversely Affect CX3CR1+ T Cell Responses

Jennifer Harcourt, Rene Alvarez, Les P. Jones, Christine Henderson, Larry J. Anderson, and Ralph A. Tripp

CD4+CD25+ Regulatory T Cells Inhibit the Antigen-Dependent Expansion of Self-Reactive T Cells In Vivo

Tricia D. Zwar, Simon Read, Ian R. van Driel, and Paul A. Gleeson

MHC Class I-Related Molecule 1-Restricted V19i Mucosal-Associated Invariant T Cells Are Innate T Cells in the Gut Lamina Propria That Provide a Rapid and Diverse Cytokine Response

Izumi Kawachi, Jorge Maldanado, Carey Strader, and Susan Gilfillan

Cross-Positive Selection of Thymocytes Expressing a Single TCR by Multiple Major Histocompatibility Complex Molecules of Both Classes: Implications for CD4+ vs CD8+ Lineage Commitment

Koji Eshima, Harumi Suzuki, and Nobukata Shinohara

Early Autoimmune Destruction of Islet Grafts Is Associated with a Restricted Repertoire of IGRP-Specific CD8+ T Cells in Diabetic Nonobese Diabetic Mice

Carmen P. Wong, Li Li, Jeffrey A. Frelinger, and Roland Tisch

NKT Cells and IFN- Establish the Regulatory Environment for the Control of Diabetogenic T Cells in the Nonobese Diabetic Mouse

Judith A. Cain, Judith A. Smith, Jennifer K. Ondr, Bo Wang, and Jonathan D. Katz

MOLECULAR AND STRUCTURAL IMMUNOLOGY

The Nucleotide Targets of Somatic Mutation and the Role of Selection in Ig Heavy Chains of a Teleost Fish

Feixue Yang, Geoffrey C. Waldbieser, and Craig J. Lobb

Meningococcal Porin PorB Binds to TLR2 and Requires TLR1 for Signaling

Paola Massari, Alberto Visintin, Jay Gunawardana, Kristen Halmen, Carol A. King, Douglas T. Golenbock, and Lee M. Wetzler

Phosphatidylinositol 3-Kinase Functions as a Ras Effector in the Signaling Cascade That Regulates Dephosphorylation of the Actin-Remodeling Protein Cofilin after Costimulation of Untransformed Human T Lymphocytes

Guido H. Wabnitz, Gabriele Nebl, Martin Klemke, Andreas J. Schroder, and Yvonne Samstag

Opioids Trigger 51 Integrin-Mediated Monocyte Adhesion

Oscar M. Pello, Beatrice Duthey, David Garcia-Bernal, Jose Miguel Rodriguez-Frade, Jens V. Stein, Joaquin Teixido, Carlos Martinez-A., and Mario Mellado

Characterization of Functional Oligosaccharide Mimics of the Shigella flexneri Serotype 2a O-Antigen: Implications for the Development of a Chemically Defined Glycoconjugate Vaccine

Armelle Phalipon, Corina Costachel, Cyrille Grandjean, Audrey Thuizat, Catherine Guerreiro, Myriam Tanguy, Farida Nato, Brigitte Vulliez-Le Normand, Frederic Belot, Karen Wright, Veronique Marcel-Peyre, Philippe J. Sansonetti, and Laurence A. Mulard

Glucocorticoids Engage Different Signal Transduction Pathways to Induce Apoptosis in Thymocytes and Mature T Cells

Dapeng Wang, Nora Muller, Kirsty G. McPherson, and Holger M. Reichardt

HOST DEFENSE

Qa-1b and CD94-NKG2a Interaction Regulate Cytolytic Activity of Herpes Simplex Virus-Specific Memory CD8+ T Cells in the Latently Infected Trigeminal Ganglia

Susmit Suvas, Ahmet Kursat Azkur, and Barry T. Rouse

Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37

Neeloffer Mookherjee, Kelly L. Brown, Dawn M. E. Bowdish, Silvana Doria, Reza Falsafi, Karsten Hokamp, Fiona M. Roche, Ruixia Mu, Gregory H. Doho, Jelena Pistolic, Jon-Paul Powers, Jenny Bryan, Fiona S. L. Brinkman, and Robert E. W. Hancock

Immunity and Tolerance to Aspergillus Involve Functionally Distinct Regulatory T Cells and Tryptophan Catabolism

Claudia Montagnoli, Francesca Fallarino, Roberta Gaziano, Silvia Bozza, Silvia Bellocchio, Teresa Zelante, Wiswanath P. Kurup, Lucia Pitzurra, Paolo Puccetti, and Luigina Romani

Experimental African Trypanosomiasis: A Subset of Pathogenic, IFN--Producing, MHC Class II-Restricted CD4+ T Cells Mediates Early Mortality in Highly Susceptible Mice

Meiqing Shi, Guojian Wei, Wanling Pan, and Henry Tabel

Respiratory Syncytial Virus Induces TLR3 Protein and Protein Kinase R, Leading to Increased Double-Stranded RNA Responsiveness in Airway Epithelial Cells

Dayna J. Groskreutz, Martha M. Monick, Linda S. Powers, Timur O. Yarovinsky, Dwight C. Look, and Gary W. Hunninghake

DC-SIGN Is a Receptor for Human Herpesvirus 8 on Dendritic Cells and Macrophages

Giovanna Rappocciolo, Frank J. Jenkins, Heather R. Hensler, Paolo Piazza, Mariel Jais, Luann Borowski, Simon C. Watkins, and Charles R. Rinaldo, Jr.

CD25+ Regulatory T Cell Depletion Augments Immunotherapy of Micrometastases by an IL-21-Secreting Cellular Vaccine

Alberto Comes, Ombretta Rosso, Anna Maria Orengo, Emma Di Carlo, Carlo Sorrentino, Raffaella Meazza, Tiziana Piazza, Barbara Valzasina, Patrizia Nanni, Mario P. Colombo, and Silvano Ferrini

Immunological Characterization and Antibacterial Function of Persisting Granulocytes in Leukemic Patients Receiving Pulse Cytosine Arabinoside-Consolidation Chemotherapy on Days 1, 3, and 5

Maria-T. Krauth, Stefan Florian, Alexandra Bohm, Karoline Sonneck, Hermine Agis, Puchit Samorapoompichit, Alexander W. Hauswirth, Wolfgang R. Sperr, and Peter Valent

Deficiency of Mannose-Binding Lectin Greatly Increases Susceptibility to Postburn Infection with Pseudomonas aeruginosa

Mette Moller-Kristensen, Eddie Ip, Lei Shi, Lakshmi D. Gowda, Michael R. Hamblin, Steffen Thiel, Jens Chr. Jensenius, R. Alan B. Ezekowitz, and Kazue Takahashi

Bacillus anthracis Edema Toxin Acts as an Adjuvant for Mucosal Immune Responses to Nasally Administered Vaccine Antigens

Alexandra Duverger, Raymond J. Jackson, Frederick W. van Ginkel, Romy Fischer, Angela Tafaro, Stephen H. Leppla, Kohtaro Fujihashi, Hiroshi Kiyono, Jerry R. McGhee, and Prosper N. Boyaka

Induction of Positive Cellular and Humoral Immune Responses by a Prime-Boost Vaccine Encoded with Simian Immunodeficiency Virus gag/pol

Kenji Someya, Yasushi Ami, Tadashi Nakasone, Yasuyuki Izumi, Kazuhiro Matsuo, Shigeo Horibata, Ke-Qin Xin, Hiroshi Yamamoto, Kenji Okuda, Naoki Yamamoto, and Mitsuo Honda

Identification of Cross-Reactive Peptides Using Combinatorial Libraries Circumvents Tolerance against Her-2/neu-Immunodominant Epitope

J. Lustgarten, A. L. Dominguez, and C. Pinilla

Human Macrophages Do Not Require Phagosome Acidification to Mediate Fungistatic/Fungicidal Activity against Histoplasma capsulatum

Simon L. Newman, Lisa Gootee, Jeremy Hilty, and Randall E. Morris

Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection

Christopher C. Kemball, Eun D. Han Lee, Eva Szomolanyi-Tsuda, Thomas C. Pearson, Christian P. Larsen, and Aron E. Lukacher

Inhibition of TCR Signaling by Herpes Simplex Virus

Derek D. Sloan, Jin-Young Han, Tracy K. Sandifer, Mary Stewart, Aaron J. Hinz, Miri Yoon, David C. Johnson, Patricia G. Spear, and Keith R. Jerome

Mimicry of Apoptotic Cells by Exposing Phosphatidylserine Participates in the Establishment of Amastigotes of Leishmania (L) amazonensis in Mammalian Hosts

Joao L. M. Wanderley, Maria E. C. Moreira, Aline Benjamin, Adriana C. Bonomo, and Marcello A. Barcinski

Induction of Suppressor of Cytokine Signaling-1 by Toxoplasma gondii Contributes to Immune Evasion in Macrophages by Blocking IFN- Signaling

Stefan Zimmermann, Peter J. Murray, Klaus Heeg, and Alexander H. Dalpke

INFLAMMATION

Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

Charles N. Serhan, Katherine Gotlinger, Song Hong, Yan Lu, Jeffrey Siegelman, Tamara Baer, Rong Yang, Sean P. Colgan, and Nicos A. Petasis

Acetyl-11-Keto--Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-B and NF-B Regulated-Gene Expression

Yasunari Takada, Haruyo Ichikawa, Vladimir Badmaev, and Bharat B. Aggarwal

Fraktalkine Produced by Airway Smooth Muscle Cells Contributes to Mast Cell Recruitment in Asthma

Amr El-Shazly, Patrick Berger, Pierre-Olivier Girodet, Olga Ousova, Michael Fayon, Jean-Marc Vernejoux, Roger Marthan, and J. Manuel Tunon-de-Lara

Corticotropin-Releasing Factor and the Urocortins Induce the Expression of TLR4 in Macrophages via Activation of the Transcription Factors PU.1 and AP-1

Christos Tsatsanis, Ariadne Androulidaki, Themis Alissafi, Ioannis Charalampopoulos, Erini Dermitzaki, Thierry Roger, Achille Gravanis, and Andrew N. Margioris

Lipoxins Redistribute Myosin IIA and Cdc42 in Macrophages: Implications for Phagocytosis of Apoptotic Leukocytes

Keira Reville, John K. Crean, Sharon Vivers, Ian Dransfield, and Catherine Godson

Proinflammatory Effects of Tweak/Fn14 Interactions in Glomerular Mesangial Cells

Sean Campbell, Linda C. Burkly, Hua-Xin Gao, Joan W. Berman, Lihe Su, Beth Browning, Timothy Zheng, Lena Schiffer, Jennifer S. Michaelson, and Chaim Putterman

Essential Role of MAPK Phosphatase-1 in the Negative Control of Innate Immune Responses

Konstantin V. Salojin, Iris B. Owusu, Karen A. Millerchip, Mark Potter, Ken A. Platt, and Tamas Oravecz

In vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin

Gamze Piskin, Regien M. R. Sylva-Steenland, Jan D. Bos, and Marcel B. M. Teunissen

Circulating Progenitor Epithelial Cells Traffic via CXCR4/CXCL12 in Response to Airway Injury

Brigitte N. Gomperts, John A. Belperio, P. Nagesh Rao, Scott H. Randell, Michael C. Fishbein, Marie D. Burdick, and Robert M. Strieter

Suppression of Discoidin Domain Receptor 1 by RNA Interference Attenuates Lung Inflammation

Wataru Matsuyama, Masaki Watanabe, Yuko Shirahama, Ryuki Hirano, Hideo Mitsuyama, Ikkou Higashimoto, Mistuhiro Osame, and Kimiyoshi Arimura

Deletion of TLR3 Alters the Pulmonary Immune Environment and Mucus Production during Respiratory Syncytial Virus Infection

Brian D. Rudd, Jetse J. Smit, Richard A. Flavell, Lena Alexopoulou, Matthew A. Schaller, Achim Gruber, Aaron A. Berlin, and Nicholas W. Lukacs

Inhibition of Chronic Airway Inflammation and Remodeling by Galectin-3 Gene Therapy in a Murine Model

Esther Lopez, Victoria del Pozo, Teresa Miguel, Beatriz Sastre, Carmen Seoane, Esther Civantos, Elena Llanes, M. Luisa Baeza, Pilar Palomino, Blanca Cardaba, Soledad Gallardo, Felix Manzarbeitia, Jose M. Zubeldia, and Carlos Lahoz

CLINICAL IMMUNOLOGY

Redundancy in Antigen-Presenting Function of the HLA-DR and -DQ Molecules in the Multiple Sclerosis-Associated HLA-DR2 Haplotype

Mireia Sospedra, Paolo A. Muraro, Irena Stefanova, Yingdong Zhao, Katherine Chung, Yili Li, Marc Giulianotti, Richard Simon, Roy Mariuzza, Clemencia Pinilla, and Roland Martin

Effacing of the T Cell Compartment by Cardiac Transplantation in Infancy

Brenda M. Ogle, Lori J. West, David J. Driscoll, Scott E. Strome, Raymund R. Razonable, Carlos V. Paya, Marilia Cascalho, and Jeffrey L. Platt

Identification of an Epitope within Human Integrin 6 Subunit for the Binding of Autoantibody and Its Role in Basement Membrane Separation in Oral Pemphigoid

Khwaja Aftab Rashid, Joel N. H. Stern, and A. Razzaque Ahmed

TLR9 Activation is Defective In Common Variable Immune Deficiency

C. Cunningham-Rundles, L. Radigan, A. K. Knight, L. Zhang, L. Bauer, and A. Nakazawa

Allelic Variation in Key Peptide-Binding Pockets Discriminates between Closely Related Diabetes-Protective and Diabetes-Susceptible HLA-DQB1 06 Alleles

Ruth A. Ettinger, George K. Papadopoulos, Antonis K. Moustakas, Gerald T. Nepom, and William W. Kwok

Predicting Tumor Outcome following Cancer Vaccination by Monitoring Quantitative and Qualitative CD8+ T Cell Parameters

Antonio Rosato, Alessia Zoso, Silvia Dalla Santa, Gabriella Milan, Paola Del Bianco, Gian Luca De Salvo, and Paola Zanovello

Pretreatment Intracerebral and Peripheral Blood Immune Responses in Vietnamese Adults with Tuberculous Meningitis: Diagnostic Value and Relationship to Disease Severity and Outcome

Cameron P. Simmons, Guy E. Thwaites, Nguyen Than Ha Quyen, Estee Torok, Dang Minh Hoang, Tran Thi Hong Chau, Pham Phuong Mai, Nguyen Thi Ngoc Lan, Nguyen Huy Dung, Hoang Thi Quy, Nguyen Duc Bang, Tran Tinh Hien, and Jeremy Farrar

Autoreactive T and B Cells from Bullous Pemphigoid (BP) Patients Recognize Epitopes Clustered in Distinct Regions of BP180 and BP230

Sybille Thoma-Uszynski, Wolfgang Uter, Susanne Schwietzke, Gerold Schuler, Luca Borradori, and Michael Hertl