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On the cover: A critical role for T cells in Aire-deficient mice. Spontaneous autoimmunity in Aire-deficient mice targets a number of different organs, including the retina. Aire-deficient mice that lack T cells are completely free of disease. In contrast, Aire-deficient mice devoid of B cells still develop autoimmunity including inflammatory infiltrates in the retina (shown). DeVoss, J. J., A. K. Shum, K. P. A. Johannes, W. Lu, A. K. Krawisz, P. Wang, T. Yang, N. P. LeClair, C. Austin, E. C. Strauss, and M. S. Anderson. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J. Immunol. 181: 4072–4079.