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On the cover: Loss of SOCS1 inhibits expression of CCR7 on T lymphocytes resulting in aberrant migration of activated effector-memory CD4+ T cells into peripheral tissues of the skin and eye. Histology section showing inflammatory cells infiltrating skin of SOCS1-deficient mice with chronic dermatitis and hyperkeratosis (H&E staining: original magnification, ×400). Yu, C-R, R. M. Mahdi, X. Liu, A. Zhang, T. Naka, T. Kishimoto and C. E. Egwuagu. 2008. SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues. J. Immunol. 181: 1190–1198.
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