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On the cover: In mice neurons, MHC-I and its NK receptor Ly49 are expressed, interact, and regulate synapse formation.In cortical ex vivo neuronal cultures, Ly49 (green) is found in neuronal soma, axons, and dendrites and colocalize with the presynaptic protein synapsin-I (red) (colocalization is yellow). Zohar, O., Y. Reiter, J. R. Bennink, A. Lev, S. Cavallaro, S. Paratore, C. G. Pick, G. Brooker, and J. W. Yewdell. 2008. Cutting edge: MHC class I–Ly49 interaction regulates neuronal function. J. Immunol. 180: 6447–6451.
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