IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2007 179: 5615-5616. [Full Text] [PDF]  

PILLARS OF IMMUNOLOGY:

Nossal and Pike 1975: A Turning Point in the Effort to Define Self-Tolerance Mechanisms

Christopher C. Goodnow
J Immunol 2007 179: 5617-5618. [Full Text] [PDF] [Original Pillars Article]  

Pillars Article: Evidence for the Clonal Abortion Theory of B-Lymphocyte Tolerance. J. Exp. Med. 1975. 141: 904–917.

G. J. V. Nossal and Beverley L. Pike
J Immunol 2007 179: 5619-5632. [PDF]  

BRIEF REVIEWS:

Perspectives on Mucosal Vaccines: Is Mucosal Tolerance a Barrier?

Jiri Mestecky, Michael W. Russell, and Charles O. Elson
J Immunol 2007 179: 5633-5638. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: Two Distinct Motifs within the Fas Ligand Tail Regulate Fas Ligand-Mediated Costimulation

Mingyi Sun, Shinhee Lee, Saoussen Karray, Matthieu Levi-Strauss, Kristina T. Ames, and Pamela J. Fink
J Immunol 2007 179: 5639-5643. [Abstract] [Full Text] [PDF]  

Cutting Edge: Modulation of Intestinal Autoimmunity and IL-2 Signaling by Sphingosine Kinase 2 Independent of Sphingosine 1-Phosphate

Eileen T. Samy, Claas A. Meyer, Patrick Caplazi, Claire L. Langrish, Jose M. Lora, Horst Bluethmann, and Stanford L. Peng
J Immunol 2007 179: 5644-5648. [Abstract] [Full Text] [PDF]  

Cutting Edge: Atypical PKCs Regulate T Lymphocyte Polarity and Scanning Behavior

Eliana Real, Sophie Faure, Emmanuel Donnadieu, and Jérôme Delon
J Immunol 2007 179: 5649-5652. [Abstract] [Full Text] [PDF]  

Cutting Edge: TCR Revision Affects Predominantly Foxp3^– Cells and Skews Them toward the Th17 Lineage

Dietmar Zehn, Michael J. Bevan, and Pamela J. Fink
J Immunol 2007 179: 5653-5657. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

How Regulatory CD25⁺CD4⁺ T Cells Impinge on Tumor Immunobiology: The Differential Response of Tumors to Therapies

Kalet Leon, Karina Garcia, Jorge Carneiro, and Agustin Lage
J Immunol 2007 179: 5659-5668. [Abstract] [Full Text] [PDF]  

Histone Acetylation at the Ifng Promoter in Tolerized CD4 Cells Is Associated with Increased IFN- Expression during Subsequent Immunization to the Same Antigen

Meixiao Long, Aaron M. Slaiby, Shuang Wu, Adam T. Hagymasi, Marianne A. Mihalyo, Suman Bandyopadhyay, Anthony T. Vella, and Adam J. Adler
J Immunol 2007 179: 5669-5677. [Abstract] [Full Text] [PDF]  

Targeting the Gut Vascular Endothelium Induces Gut Effector CD8 T Cell Responses Via Cross-Presentation by Dendritic Cells

Dorothee Bourges, Yifan Zhan, Jamie L. Brady, Hal Braley, Irina Caminschi, Sandro Prato, José A. Villadangos, and Andrew M. Lew
J Immunol 2007 179: 5678-5685. [Abstract] [Full Text] [PDF]  

A Distinct Role of Neutrophil Lactoferrin in RelA/p65 Phosphorylation on Ser⁵³⁶ by Recruiting TNF Receptor-Associated Factors to IB Kinase Signaling Complex

Sang-Muk Oh, Shin-Hee Lee, Bum-Jin Lee, Chul-Woong Pyo, Na-Kyung Yoo, Soo Young Lee, Jiyoung Kim, and Sang-Yun Choi
J Immunol 2007 179: 5686-5692. [Abstract] [Full Text] [PDF]  

Lymphotoxin Pathway and Aire Influences on Thymic Medullary Epithelial Cells Are Unconnected

Emily S. Venanzi, Daniel H. D. Gray, Christophe Benoist, and Diane Mathis
J Immunol 2007 179: 5693-5700. [Abstract] [Full Text] [PDF] Data Supplement  

Sialyl-Lewis^x on P-Selectin Glycoprotein Ligand-1 Is Regulated during Differentiation and Maturation of Dendritic Cells: A Mechanism Involving the Glycosyltransferases C2GnT1 and ST3Gal I

Sylvain Julien, Matthew J. Grimshaw, Mark Sutton-Smith, Julia Coleman, Howard R. Morris, Anne Dell, Joyce Taylor-Papadimitriou, and Joy M. Burchell
J Immunol 2007 179: 5701-5710. [Abstract] [Full Text] [PDF]  

Calcineurin Inhibitors Block MHC-Restricted Antigen Presentation In Vivo

Young-Hee Lee, Young-Ran Lee, Sun-A Im, Sun-Im Park, Ki-Hyang Kim, Turmunkh Gerelchuluun, Sukgil Song, Kyungjae Kim, and Chong-Kil Lee
J Immunol 2007 179: 5711-5716. [Abstract] [Full Text] [PDF]  

Molecular Architecture of the TAP-Associated MHC Class I Peptide-Loading Complex

Elke Rufer, Ralf M. Leonhardt, and Michael R. Knittler
J Immunol 2007 179: 5717-5727. [Abstract] [Full Text] [PDF]  

Differential Regulation of the Nature and Functions of Dendritic Cells and Macrophages by Cathepsin E

Hiroe Kakehashi, Tsuyoshi Nishioku, Takayuki Tsukuba, Tomoko Kadowaki, Seiji Nakamura, and Kenji Yamamoto
J Immunol 2007 179: 5728-5737. [Abstract] [Full Text] [PDF]  

Increasing the Survival of Dendritic Cells In Vivo Does Not Replace the Requirement for CD4⁺ T Cell Help during Primary CD8⁺ T Cell Responses

Kate E. Matthews, Jim S. Qin, Jianping Yang, Ian F. Hermans, Michael J. Palmowski, Vincenzo Cerundolo, and Franca Ronchese
J Immunol 2007 179: 5738-5747. [Abstract] [Full Text] [PDF]  

Allergic Airways Disease Develops after an Increase in Allergen Capture and Processing in the Airway Mucosa

Christophe von Garnier, Matthew E. Wikstrom, Graeme Zosky, Debra J. Turner, Peter D. Sly, Miranda Smith, Jennifer A. Thomas, Samantha R. Judd, Deborah H. Strickland, Patrick G. Holt, and Philip A. Stumbles
J Immunol 2007 179: 5748-5759. [Abstract] [Full Text] [PDF]  

Recruitment and Activation of Macrophages by Pathogenic CD4 T Cells in Type 1 Diabetes: Evidence for Involvement of CCR8 and CCL1

Joseph Cantor and Kathryn Haskins
J Immunol 2007 179: 5760-5767. [Abstract] [Full Text] [PDF]  

Extent of Stimulation Controls the Formation of Memory CD8 T Cells

Michael Quigley, Xiaopei Huang, and Yiping Yang
J Immunol 2007 179: 5768-5777. [Abstract] [Full Text] [PDF]  

Syndecan-4 Mediates the Coinhibitory Function of DC-HIL on T Cell Activation

Jin-Sung Chung, Irene Dougherty, Ponciano D. Cruz, Jr., and Kiyoshi Ariizumi
J Immunol 2007 179: 5778-5784. [Abstract] [Full Text] [PDF]  

Evidence for In Vivo Primed and Expanded Autoreactive T Cells as a Specific Feature of Patients with Type 1 Diabetes

Paolo Monti, Miriam Scirpoli, Andrea Rigamonti, Anya Mayr, Annika Jaeger, Riccardo Bonfanti, Giuseppe Chiumello, Anette G. Ziegler, and Ezio Bonifacio
J Immunol 2007 179: 5785-5792. [Abstract] [Full Text] [PDF]  

Decay Accelerating Factor Can Control T Cell Differentiation into IFN--Producing Effector Cells via Regulating Local C5a-Induced IL-12 Production

Peter N. Lalli, Michael G. Strainic, Feng Lin, M. Edward Medof, and Peter S. Heeger
J Immunol 2007 179: 5793-5802. [Abstract] [Full Text] [PDF]  

Targeting the Wilms Tumor Antigen 1 by TCR Gene Transfer: TCR Variants Improve Tetramer Binding but Not the Function of Gene Modified Human T Cells

Sharyn Thomas, Shao-An Xue, Michela Cesco-Gaspere, Esther San José, Daniel P. Hart, Vivian Wong, Reno Debets, Balbino Alarcon, Emma Morris, and Hans J. Stauss
J Immunol 2007 179: 5803-5810. [Abstract] [Full Text] [PDF]  

IL-6 and Maturation Govern TLR2 and TLR4 Induced TLR Agonist Tolerance and Cross-Tolerance in Dendritic Cells

Julia Geisel, Frauke Kahl, Martina Müller, Hermann Wagner, Carsten J. Kirschning, Ingo B. Autenrieth, and Julia-Stefanie Frick
J Immunol 2007 179: 5811-5818. [Abstract] [Full Text] [PDF]  

Autoimmunity Stimulated by Adoptively Transferred Dendritic Cells Is Initiated by Both and T Cells but Does Not Require MyD88 Signaling

David A. Martin, Kang Zhang, Justin Kenkel, Grant Hughes, Edward Clark, Anne Davidson, and Keith B. Elkon
J Immunol 2007 179: 5819-5828. [Abstract] [Full Text] [PDF]  

Cognate Memory CD4⁺ T Cells Generated with Dendritic Cell Priming Influence the Expansion, Trafficking, and Differentiation of Secondary CD8⁺ T Cells and Enhance Tumor Control

Melissa L. Hwang, John R. Lukens, and Timothy N. J. Bullock
J Immunol 2007 179: 5829-5838. [Abstract] [Full Text] [PDF]  

A Functionally Coupled µ3-Like Opiate Receptor/Nitric Oxide Regulatory Pathway in Human Multi-Lineage Progenitor Cells

Patrick Cadet, Kirk J. Mantione, Wei Zhu, Richard M. Kream, Melinda Sheehan, and George B. Stefano
J Immunol 2007 179: 5839-5844. [Abstract] [Full Text] [PDF]  

High-Affinity TCRs Generated by Phage Display Provide CD4⁺ T Cells with the Ability to Recognize and Kill Tumor Cell Lines

Yangbing Zhao, Alan D. Bennett, Zhili Zheng, Qiong J. Wang, Paul F. Robbins, Lawrence Y. L. Yu, Yi Li, Peter E. Molloy, Steven M. Dunn, Bent K. Jakobsen, Steven A. Rosenberg, and Richard A. Morgan
J Immunol 2007 179: 5845-5854. [Abstract] [Full Text] [PDF]  

Sphingosine-1 Phosphate Signaling Regulates Positioning of Dendritic Cells within the Spleen

Niklas Czeloth, Angela Schippers, Norbert Wagner, Werner Müller, Birgit Küster, Günter Bernhardt, and Reinhold Förster
J Immunol 2007 179: 5855-5863. [Abstract] [Full Text] [PDF]  

Quantitative Time-Resolved Phosphoproteomic Analysis of Mast Cell Signaling

Lulu Cao, Kebing Yu, Cindy Banh, Vinh Nguyen, Anna Ritz, Benjamin J. Raphael, Yuko Kawakami, Toshiaki Kawakami, and Arthur R. Salomon
J Immunol 2007 179: 5864-5876. [Abstract] [Full Text] [PDF] Data Supplement  

B Cell Activation State-Governed Formation of Germinal Centers following Viral Infection

Katja Fink, Nataly Manjarrez-Orduño, Anita Schildknecht, Jacqueline Weber, Beatrice M. Senn, Rolf M. Zinkernagel, and Hans Hengartner
J Immunol 2007 179: 5877-5885. [Abstract] [Full Text] [PDF]  

Essential Role of IL-21 in B Cell Activation, Expansion, and Plasma Cell Generation during CD4⁺ T Cell-B Cell Collaboration

Stefan Kuchen, Rachel Robbins, Gary P. Sims, Chen Sheng, Terence M. Phillips, Peter E. Lipsky, and Rachel Ettinger
J Immunol 2007 179: 5886-5896. [Abstract] [Full Text] [PDF]  

Regulatory Role of Lymphoid Chemokine CCL19 and CCL21 in the Control of Allergic Rhinitis

Kaoru Takamura, Satoshi Fukuyama, Takahiro Nagatake, Dong-Young Kim, Aya Kawamura, Hideyuki Kawauchi, and Hiroshi Kiyono
J Immunol 2007 179: 5897-5906. [Abstract] [Full Text] [PDF]  

Posttranslational Regulation of I-E^d by Affinity for CLIP

Cornelia H. Rinderknecht, Michael P. Belmares, Tatiana L. W. Catanzarite, Alexander J. Bankovich, Tyson H. Holmes, K. Christopher Garcia, Navreet K. Nanda, Robert Busch, Susan Kovats, and Elizabeth D. Mellins
J Immunol 2007 179: 5907-5915. [Abstract] [Full Text] [PDF]  

Glucocorticoid-Induced TNFR-Related Protein Lowers the Threshold of CD28 Costimulation in CD8⁺ T Cells

Simona Ronchetti, Giuseppe Nocentini, Rodolfo Bianchini, L. Tibor Krausz, Graziella Migliorati, and Carlo Riccardi
J Immunol 2007 179: 5916-5926. [Abstract] [Full Text] [PDF]  

Cyclosporin A Suspends Transplantation Reactions in the Marine Sponge Microciona prolifera

Clarissa Sabella, Ellen Faszewski, Lisa Himic, Katherine M. Colpitts, Jane Kaltenbach, Max M. Burger, and Xavier Fernàndez-Busquets
J Immunol 2007 179: 5927-5935. [Abstract] [Full Text] [PDF] Data Supplement  

CD86 Has Sustained Costimulatory Effects on CD8 T Cells

Ian J. Thomas, Liliana G. Petrich de Marquesini, Rommel Ravanan, Richard M. Smith, Sylvie Guerder, Richard A. Flavell, David C. Wraith, Li Wen, and F. Susan Wong
J Immunol 2007 179: 5936-5946. [Abstract] [Full Text] [PDF]  

In Vitro and In Vivo Activation Induces BAFF and APRIL Expression in B Cells

Van Trung Chu, Philipp Enghard, Gabriela Riemekasten, and Claudia Berek
J Immunol 2007 179: 5947-5957. [Abstract] [Full Text] [PDF]  

Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis

Zhaojun Wang, Ju Qiu, Taylor B. Guo, Ailian Liu, Ying Wang, Yin Li, and Jingwu Z. Zhang
J Immunol 2007 179: 5958-5965. [Abstract] [Full Text] [PDF]  

Molecular Mechanism of Lipopolysaccharide-Induced SOCS-3 Gene Expression in Macrophages and Microglia

Hongwei Qin, Kevin L. Roberts, Sandrine A. Niyongere, Yingzi Cong, Charles O. Elson, and Etty N. Benveniste
J Immunol 2007 179: 5966-5976. [Abstract] [Full Text] [PDF]  

Hierarchy of the Human Natural Killer Cell Response Is Determined by Class and Quantity of Inhibitory Receptors for Self-HLA-B and HLA-C Ligands

Junli Yu, Glenn Heller, Joseph Chewning, Sungjin Kim, Wayne M. Yokoyama, and Katharine C. Hsu
J Immunol 2007 179: 5977-5989. [Abstract] [Full Text] [PDF]  

Jagged1 and Delta1 Differentially Regulate the Outcome of Experimental Autoimmune Encephalomyelitis

Wassim Elyaman, Elizabeth M. Bradshaw, Yue Wang, Mohamed Oukka, Pia Kivisäkk, Shigeru Chiba, Hideo Yagita, and Samia J. Khoury
J Immunol 2007 179: 5990-5998. [Abstract] [Full Text] [PDF]  

Functional yet Balanced Reactivity to Candida albicans Requires TRIF, MyD88, and IDO-Dependent Inhibition of Rorc

Antonella De Luca, Claudia Montagnoli, Teresa Zelante, Pierluigi Bonifazi, Silvia Bozza, Silvia Moretti, Carmen D’Angelo, Carmine Vacca, Louis Boon, Francesco Bistoni, Paolo Puccetti, Francesca Fallarino, and Luigina Romani
J Immunol 2007 179: 5999-6008. [Abstract] [Full Text] [PDF]  

A Crucial Role for Dendritic Cell (DC) IL-10 in Inhibiting Successful DC-Based Immunotherapy: Superior Antitumor Immunity against Hepatocellular Carcinoma Evoked by DC Devoid of IL-10

Yu-Xiao Chen, Kwan Man, Guang Sheng Ling, Yichen Chen, Bai-Shun Sun, Qiao Cheng, On Hong Wong, Chi-Kin Lo, Irene Oi-Lin Ng, Li Chong Chan, George K. Lau, Chen-Lung Steve Lin, Fanglu Huang, and Fang-Ping Huang
J Immunol 2007 179: 6009-6015. [Abstract] [Full Text] [PDF]  

Purinergic P2Y₂ Receptors Induce Increased MCP-1/CCL2 Synthesis and Release from Rat Alveolar and Peritoneal Macrophages

Leanne Stokes and Annmarie Surprenant
J Immunol 2007 179: 6016-6023. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Geranylgeranylation but Not GTP Loading Determines Rho Migratory Function in T Cells

Sonia Waiczies, Ivo Bendix, Timour Prozorovski, Maya Ratner, Irina Nazarenko, Caspar F. Pfueller, Alexander U. Brandt, Josephine Herz, Stefan Brocke, Oliver Ullrich, and Frauke Zipp
J Immunol 2007 179: 6024-6032. [Abstract] [Full Text] [PDF]  

The 3' IgH Locus Control Region Is Sufficient to Deregulate a c-myc Transgene and Promote Mature B Cell Malignancies with a Predominant Burkitt-Like Phenotype

Véronique Truffinet, Eric Pinaud, Nadine Cogné, Barbara Petit, Laurence Guglielmi, Michel Cogné, and Yves Denizot
J Immunol 2007 179: 6033-6042. [Abstract] [Full Text] [PDF] Data Supplement  

TGF-1 Induces Progressive Pleural Scarring and Subpleural Fibrosis

Nathalie Decologne, Martin Kolb, Peter J. Margetts, Franck Menetrier, Yves Artur, Carmen Garrido, Jack Gauldie, Philippe Camus, and Philippe Bonniaud
J Immunol 2007 179: 6043-6051. [Abstract] [Full Text] [PDF]  

The Novel Endocytic and Phagocytic C-Type Lectin Receptor DCL-1/CD302 on Macrophages Is Colocalized with F-Actin, Suggesting a Role in Cell Adhesion and Migration

Masato Kato, Seema Khan, Elisabetta d’Aniello, Kylie J. McDonald, and Derek N. J. Hart
J Immunol 2007 179: 6052-6063. [Abstract] [Full Text] [PDF]  

Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G₁ Phase of the Cell Cycle and Depend upon Mismatch Repair

Carol E. Schrader, Jeroen E. J. Guikema, Erin K. Linehan, Erik Selsing, and Janet Stavnezer
J Immunol 2007 179: 6064-6071. [Abstract] [Full Text] [PDF]  

IMMUNOGENETICS:

Mast Cell and Tryptases Changed Rapidly during Primate Speciation and Evolved from -Like Transmembrane Peptidases in Ancestral Vertebrates

Neil N. Trivedi, Qiao Tong, Kavita Raman, Vikash J. Bhagwandin, and George H. Caughey
J Immunol 2007 179: 6072-6079. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

A Monocyte-Specific Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Activates the NADPH-Oxidase but Not Chemotaxis through a G-Protein-Coupled Receptor Distinct from the Members of the Formyl Peptide Receptor Family

Lars Bellner, Jennie Karlsson, Huamei Fu, François Boulay, Claes Dahlgren, Kristina Eriksson, and Anna Karlsson
J Immunol 2007 179: 6080-6087. [Abstract] [Full Text] [PDF]  

Pregnancy Impairs the Innate Immune Resistance to Salmonella typhimurium Leading to Rapid Fatal Infection

Branka Pejcic-Karapetrovic, Komal Gurnani, Marsha S. Russell, B. Brett Finlay, Subash Sad, and Lakshmi Krishnan
J Immunol 2007 179: 6088-6096. [Abstract] [Full Text] [PDF]  

Tobacco Smoking Inhibits Expression of Proinflammatory Cytokines and Activation of IL-1R-Associated Kinase, p38, and NF-B in Alveolar Macrophages Stimulated with TLR2 and TLR4 Agonists

Haiyan Chen, Mark J. Cowan, Jeffrey D. Hasday, Stefanie N. Vogel, and Andrei E. Medvedev
J Immunol 2007 179: 6097-6106. [Abstract] [Full Text] [PDF]  

TLR4/MD-2 Monoclonal Antibody Therapy Affords Protection in Experimental Models of Septic Shock

Bruno Daubeuf, John Mathison, Stephan Spiller, Stephanie Hugues, Suzanne Herren, Walter Ferlin, Marie Kosco-Vilbois, Hermann Wagner, Carsten J. Kirschning, Richard Ulevitch, and Greg Elson
J Immunol 2007 179: 6107-6114. [Abstract] [Full Text] [PDF]  

Characterization of Antigen-Specific Immune Responses Induced by Canarypox Virus Vaccines

Rinke Bos, Suzanne van Duikeren, Thorbald van Hall, Marjolein M. Lauwen, Mark Parrington, Neil L. Berinstein, Bryan McNeil, Cornelis J. M. Melief, J. Sjef Verbeek, Sjoerd H. van der Burg, and Rienk Offringa
J Immunol 2007 179: 6115-6122. [Abstract] [Full Text] [PDF]  

Differential Type I IFN-Inducing Abilities of Wild-Type versus Vaccine Strains of Measles Virus

Masashi Shingai, Takashi Ebihara, Nasim A. Begum, Atsushi Kato, Toshiki Honma, Kenji Matsumoto, Hirohisa Saito, Hisashi Ogura, Misako Matsumoto, and Tsukasa Seya
J Immunol 2007 179: 6123-6133. [Abstract] [Full Text] [PDF]  

TLR2 and Caspase-8 Are Essential for Group B Streptococcus-Induced Apoptosis in Microglia

Seija Lehnardt, Julia Wennekamp, Dorette Freyer, Christian Liedtke, Christina Krueger, Robert Nitsch, Ingo Bechmann, Joerg R. Weber, and Philipp Henneke
J Immunol 2007 179: 6134-6143. [Abstract] [Full Text] [PDF]  

Stromal Complement Receptor CD21/35 Facilitates Lymphoid Prion Colonization and Pathogenesis

Mark D. Zabel, Mathias Heikenwalder, Marco Prinz, Isabelle Arrighi, Petra Schwarz, Jan Kranich, Adriana von Teichman, Karen M. Haas, Nicolas Zeller, Thomas F. Tedder, John H. Weis, and Adriano Aguzzi
J Immunol 2007 179: 6144-6152. [Abstract] [Full Text] [PDF]  

Rectification of Age-Associated Deficiency in Cytotoxic T Cell Response to Influenza A Virus by Immunization with Immune Complexes

Biao Zheng, Yongxin Zhang, Hongxia He, Ekaterina Marinova, Kirsten Switzer, Daniel Wansley, Innocent Mbawuike, and Shuhua Han
J Immunol 2007 179: 6153-6159. [Abstract] [Full Text] [PDF]  

VAP-1-Deficient Mice Display Defects in Mucosal Immunity and Antimicrobial Responses: Implications for Antiadhesive Applications

Kaisa Koskinen, Suvi Nevalainen, Marika Karikoski, Arno Hänninen, Sirpa Jalkanen, and Marko Salmi
J Immunol 2007 179: 6160-6168. [Abstract] [Full Text] [PDF]  

Salmonella Flagellin Induces Bystander Activation of Splenic Dendritic Cells and Hinders Bacterial Replication In Vivo

Rosa-Maria Salazar-Gonzalez, Aparna Srinivasan, Amanda Griffin, Guruprasaadh Muralimohan, James M. Ertelt, Rajesh Ravindran, Anthony T. Vella, and Stephen J. McSorley
J Immunol 2007 179: 6169-6175. [Abstract] [Full Text] [PDF]  

IFN--Mediated Inflammatory Responses and Antiviral Defense in Liver Is TLR9-Independent but MyD88-Dependent during Murine Cytomegalovirus Infection

Kirsten L. Hokeness-Antonelli, Meredith J. Crane, Ana M. Dragoi, Wen-Ming Chu, and Thais P. Salazar-Mather
J Immunol 2007 179: 6176-6183. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Elastin Receptor (Spliced Galactosidase) Occupancy by Elastin Peptides Counteracts Proinflammatory Cytokine Expression in Lipopolysaccharide-Stimulated Human Monocytes through NF-B Down-Regulation

Thomas Baranek, Romain Debret, Frank Antonicelli, Bouchaib Lamkhioued, Azzaq Belaaouaj, William Hornebeck, Philippe Bernard, Moncef Guenounou, and Richard Le Naour
J Immunol 2007 179: 6184-6192. [Abstract] [Full Text] [PDF]  

Prostaglandin I₂-IP Signaling Blocks Allergic Pulmonary Inflammation by Preventing Recruitment of CD4⁺ Th2 Cells into the Airways in a Mouse Model of Asthma

Zeina Jaffar, Maria E. Ferrini, Mary C. Buford, Garret A. FitzGerald, and Kevan Roberts
J Immunol 2007 179: 6193-6203. [Abstract] [Full Text] [PDF]  

Urocortin Modulates Inflammatory Response and Neurotoxicity Induced by Microglial Activation

Mei-Jen Wang, Shinn-Zong Lin, Jon-Son Kuo, Hsin-Yi Huang, Shih-Fang Tzeng, Chia-Hsin Liao, Der-Cherng Chen, and Wu-Fu Chen
J Immunol 2007 179: 6204-6214. [Abstract] [Full Text] [PDF]  

Lipopolysaccharide, IFN-, and IFN- Induce Expression of the Thiol-Sensitive ART2.1 Ecto-ADP-Ribosyltransferase in Murine Macrophages

Shiyuan Hong, Anette Brass, Michel Seman, Friedrich Haag, Friedrich Koch-Nolte, and George R. Dubyak
J Immunol 2007 179: 6215-6227. [Abstract] [Full Text] [PDF]  

Exacerbation of Antigen-Induced Arthritis in IFN--Deficient Mice As a Result of Unrestricted IL-17 Response

Ingo M. Irmler, Mieczyslaw Gajda, and Rolf Bräuer
J Immunol 2007 179: 6228-6236. [Abstract] [Full Text] [PDF]  

The Role of IB Kinase 2, but Not Activation of NF-B, in the Release of CXCR3 Ligands from IFN--Stimulated Human Bronchial Epithelial Cells

Susan J. Tudhope, Matthew C. Catley, Peter S. Fenwick, Richard E. K. Russell, William L. Rumsey, Robert Newton, Peter J. Barnes, and Louise E. Donnelly
J Immunol 2007 179: 6237-6245. [Abstract] [Full Text] [PDF]  

Biomechanical Signals Suppress TAK1 Activation to Inhibit NF-B Transcriptional Activation in Fibrochondrocytes

Shashi Madhavan, Mirela Anghelina, Danen Sjostrom, Anar Dossumbekova, Denis C. Guttridge, and Sudha Agarwal
J Immunol 2007 179: 6246-6254. [Abstract] [Full Text] [PDF]  

The Role of Dendritic Cells in the Development of Acute Dextran Sulfate Sodium Colitis

Bradford E. Berndt, Min Zhang, Gwo-Hsiao Chen, Gary B. Huffnagle, and John Y. Kao
J Immunol 2007 179: 6255-6262. [Abstract] [Full Text] [PDF]  

Vasoactive Hormone Adrenomedullin and Its Binding Protein: Anti-Inflammatory Effects by Up-Regulating Peroxisome Proliferator-Activated Receptor-

Michael Miksa, Rongqian Wu, Xiaoxuan Cui, Weifeng Dong, Padmalaya Das, H. Hank Simms, Thanjavur S. Ravikumar, and Ping Wang
J Immunol 2007 179: 6263-6272. [Abstract] [Full Text] [PDF]  

Topically Applied 1,25-Dihydroxyvitamin D₃ Enhances the Suppressive Activity of CD4⁺CD25⁺ Cells in the Draining Lymph Nodes

Shelley Gorman, L. Alexandra Kuritzky, Melinda A. Judge, Katie M. Dixon, Jacqueline P. McGlade, Rebecca S. Mason, John J. Finlay-Jones, and Prue H. Hart
J Immunol 2007 179: 6273-6283. [Abstract] [Full Text] [PDF]  

Estradiol Attenuates Lipopolysaccharide-Induced CXC Chemokine Ligand 8 Production by Human Peripheral Blood Monocytes

Patricia A. Pioli, Amy L. Jensen, Lehn K. Weaver, Eyal Amiel, Zheng Shen, Li Shen, Charles R. Wira, and Paul M. Guyre
J Immunol 2007 179: 6284-6290. [Abstract] [Full Text] [PDF]  

Heat Shock Protein 90 Associates with Monarch-1 and Regulates Its Ability to Promote Degradation of NF-B-Inducing Kinase

Janelle C. Arthur, John D. Lich, Ramy K. Aziz, Malak Kotb, and Jenny P.-Y. Ting
J Immunol 2007 179: 6291-6296. [Abstract] [Full Text] [PDF]  

Nerve Growth Factor Promotes TLR4 Signaling-Induced Maturation of Human Dendritic Cells In Vitro through Inducible p75^{NTR 1}

Yingming Jiang, Guoyou Chen, Yi Zhang, Lin Lu, Shuxun Liu, and Xuetao Cao
J Immunol 2007 179: 6297-6304. [Abstract] [Full Text] [PDF]  

HVEM Signaling in Monocytes Is Mediated by Intracellular Calcium Mobilization

Sook-Kyoung Heo, Min-A Yoon, Sang-Chul Lee, Seong-A Ju, Jang-Hyun Choi, Pann-Ghill Suh, Byoung S. Kwon, and Byung-Sam Kim
J Immunol 2007 179: 6305-6310. [Abstract] [Full Text] [PDF]  

Complement Dependent Amplification of the Innate Response to a Cognate Microbial Ligand by the Long Pentraxin PTX3

Alessia Cotena, Virginia Maina, Marina Sironi, Barbara Bottazzi, Pascale Jeannin, Annunciata Vecchi, Nathalie Corvaia, Mohamed R. Daha, Alberto Mantovani, and Cecilia Garlanda
J Immunol 2007 179: 6311-6317. [Abstract] [Full Text] [PDF]  

Hsp72 Induces Inflammation and Regulates Cytokine Production in Airway Epithelium through a TLR4- and NF-B-Dependent Mechanism

Margaret A. Chase, Derek S. Wheeler, Kristin M. Lierl, Valerie S. Hughes, Hector R. Wong, and Kristen Page
J Immunol 2007 179: 6318-6324. [Abstract] [Full Text] [PDF]  

Macrophages from 11-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice Exhibit an Increased Sensitivity to Lipopolysaccharide Stimulation Due to TGF--Mediated Up-Regulation of SHIP1 Expression

Tian Y. Zhang and Raymond A. Daynes
J Immunol 2007 179: 6325-6335. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Decline in the Frequencies of Borrelia burgdorferi OspA_161–175-Specific T Cells after Antibiotic Therapy in HLA-DRB1*0401-Positive Patients with Antibiotic-Responsive or Antibiotic-Refractory Lyme Arthritis

Priya Kannian, Elise E. Drouin, Lisa Glickstein, William W. Kwok, Gerald T. Nepom, and Allen C. Steere
J Immunol 2007 179: 6336-6342. [Abstract] [Full Text] [PDF]  

V_H4 Gene Segments Dominate the Intrathecal Humoral Immune Response in Multiple Sclerosis

Gregory P. Owens, Kimberly M. Winges, Alanna M. Ritchie, Sydni Edwards, Mark P. Burgoon, Laura Lehnhoff, Kirsten Nielsen, John Corboy, Donald H. Gilden, and Jeffrey L. Bennett
J Immunol 2007 179: 6343-6351. [Abstract] [Full Text] [PDF]  

Demethylation of CD40LG on the Inactive X in T Cells from Women with Lupus

Qianjin Lu, Ailing Wu, Laura Tesmer, Donna Ray, Neda Yousif, and Bruce Richardson
J Immunol 2007 179: 6352-6358. [Abstract] [Full Text] [PDF]  

The Rheumatoid Arthritis Shared Epitope Triggers Innate Immune Signaling via Cell Surface Calreticulin

Song Ling, Xiujun Pi, and Joseph Holoshitz
J Immunol 2007 179: 6359-6367. [Abstract] [Full Text] [PDF]  

CORRECTIONS:

Protection from lethal infection by adoptive transfer of CD8 T cells genetically engineered to express virus-specific innate immune receptor.

K. Iizuka, C. Nakajima, Y.-M. Iizuka, M. Takase, T. Kato, S. Noda, K. Tanaka, and O. Kanagawa
J Immunol 2007 179: 6368. [Full Text] [PDF]  

The endothelial cell-produced anti-angiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation.

F. Tian, S. Grimaldo, M. Fugita, J. Cutts, N. L. Vujanovic, and L.-Y. Li
J Immunol 2007 179: 6369. [Full Text] [PDF]  

Bruton’s tyrosine kinase mediates NF-B activation and B cell survival by B cell-activating factor receptor of the TNF-R family.

N. P. Shinners, G. Carlesso, I. Castro, K. L. Hoek, R. A. Corn, R. L. Woodland, M. L. Scott, D. Wang, and W. N. Khan
J Immunol 2007 179: 6369. [Full Text] [PDF]  

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