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On the cover: Cleavage sites on factor VIII (FVIII) for FVIII-hydrolyzing IgG from patients with hemophilia A depicted on the five-domain model for FVIII available on the HAMSTeRS website (http://europium.csc.mrc.ac.uk) courtesy of Dr. Geoffrey Kemball-Cook. The A1, A2, A3, C1, and C2 domains of FVIII are shown in orange, green, blue, yellow, and white, respectively. Residues surrounding cleavage sites on FVIII for IgG from three patients are indicated as red spheres. Lacroix-Desmazes, S., B. Wootla, S. Dasgupta, S. Delignat, J. Bayry, J. Reinbolt, J. Hoebeke, E. Saenko, M. D. Kazatchkine, A. Friboulet, O. Christophe, V. Nagaraja, and S. V. Kaveri. 2006. Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII. J. Immunol. 177: 1355–1363.
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