IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2006 177: 6571-6572. [Full Text] [PDF]  

BRIEF REVIEWS:

Nucleic Acid-Sensing TLRs as Modifiers of Autoimmunity

Jonathan A. Deane and Silvia Bolland
J Immunol 2006 177: 6573-6578. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: CD4 Is the Receptor for the Tick Saliva Immunosuppressor, Salp15

Renu Garg, Ignacio J. Juncadella, Nandhini Ramamoorthi, Ashish, Shobana K. Ananthanarayanan, Venetta Thomas, Mercedes Rincón, Joanna K. Krueger, Erol Fikrig, Christopher M. Yengo, and Juan Anguita
J Immunol 2006 177: 6579-6583. [Abstract] [Full Text] [PDF]  

Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides

Keith K. B. Gorden, Xiaohong X. Qiu, Christine C. A. Binsfeld, John P. Vasilakos, and Sefik S. Alkan
J Immunol 2006 177: 6584-6587. [Abstract] [Full Text] [PDF]  

Cutting Edge: Resistance to HIV-1 Infection among African Female Sex Workers Is Associated with Inhibitory KIR in the Absence of Their HLA Ligands

Wim Jennes, Sonja Verheyden, Christian Demanet, Christiane A. Adjé-Touré, Bea Vuylsteke, John N. Nkengasong, and Luc Kestens
J Immunol 2006 177: 6588-6592. [Abstract] [Full Text] [PDF]  

Cutting Edge: Inherent and Acquired Resistance to Radiation-Induced Apoptosis in B Cells: A Pivotal Role for STAT3

Dennis C. Otero, Valeria Poli, Michael David, and Robert C. Rickert
J Immunol 2006 177: 6593-6597. [Abstract] [Full Text] [PDF]  

Cutting Edge: The Phosphoinositide 3-Kinase p110 Is Critical for the Function of CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells

Daniel T. Patton, Oliver A. Garden, Wayne P. Pearce, Louise E. Clough, Clare R. Monk, Eva Leung, Wendy C. Rowan, Sara Sancho, Lucy S. K. Walker, Bart Vanhaesebroeck, and Klaus Okkenhaug
J Immunol 2006 177: 6598-6602. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells

Sven Brode, Tim Raine, Paola Zaccone, and Anne Cooke
J Immunol 2006 177: 6603-6612. [Abstract] [Full Text] [PDF]  

Coreceptor Signal Strength Regulates Positive Selection but Does Not Determine CD4/CD8 Lineage Choice in a Physiologic In Vivo Model

Batu Erman, Amala S. Alag, Oyvind Dahle, François van Laethem, Sophia D. Sarafova, Terry I. Guinter, Susan O. Sharrow, Alexander Grinberg, Paul E. Love, and Alfred Singer
J Immunol 2006 177: 6613-6625. [Abstract] [Full Text] [PDF]  

Prime-Boost with Alternating DNA Vaccines Designed to Engage Different Antigen Presentation Pathways Generates High Frequencies of Peptide-Specific CD8⁺ T Cells

Joanna N. Radcliffe, Joanne S. Roddick, Peter S. Friedmann, Freda K. Stevenson, and Stephen M. Thirdborough
J Immunol 2006 177: 6626-6633. [Abstract] [Full Text] [PDF]  

Antibody Responses to Mycobacterial and Self Heat Shock Protein 65 in Autoimmune Arthritis: Epitope Specificity and Implication in Pathogenesis

Hong Ro Kim, Eugene Y. Kim, Jan Cerny, and Kamal D. Moudgil
J Immunol 2006 177: 6634-6641. [Abstract] [Full Text] [PDF]  

Functional Dichotomy in CD40 Reciprocally Regulates Effector T Cell Functions

Gopal Murugaiyan, Reena Agrawal, Gyan C. Mishra, Debashis Mitra, and Bhaskar Saha
J Immunol 2006 177: 6642-6649. [Abstract] [Full Text] [PDF]  

GATA-3 Regulates the Development and Function of Invariant NKT Cells

Peter J. Kim, Sung-Yun Pai, Manfred Brigl, Gurdyal S. Besra, Jenny Gumperz, and I-Cheng Ho
J Immunol 2006 177: 6650-6659. [Abstract] [Full Text] [PDF]  

Immature CD4⁺CD8⁺ Thymocytes and Mature T Cells Regulate Nur77 Distinctly in Response to TCR Stimulation

Nicole R. Cunningham, Stephen C. Artim, Christen M. Fornadel, MacLean C. Sellars, Samuel G. Edmonson, Grant Scott, Frank Albino, Akriti Mathur, and Jennifer A. Punt
J Immunol 2006 177: 6660-6666. [Abstract] [Full Text] [PDF]  

Specific and Redundant Roles for NFAT Transcription Factors in the Expression of Mast Cell-Derived Cytokines

Matthias Klein, Stefan Klein-Hessling, Alois Palmetshofer, Edgar Serfling, Christine Tertilt, Tobias Bopp, Valeska Heib, Marc Becker, Christian Taube, Hansjörg Schild, Edgar Schmitt, and Michael Stassen
J Immunol 2006 177: 6667-6674. [Abstract] [Full Text] [PDF]  

Partial versus Full Allogeneic Hemopoietic Chimerization Is a Preferential Means to Inhibit Type 1 Diabetes as the Latter Induces Generalized Immunosuppression

David V. Serreze, Melissa A. Osborne, Yi-Guang Chen, Harold D. Chapman, Todd Pearson, Michael A. Brehm, and Dale L. Greiner
J Immunol 2006 177: 6675-6684. [Abstract] [Full Text] [PDF]  

Death of CD4⁺ T Cells from Lymph Nodes during Primary SIVmac251 Infection Predicts the Rate of AIDS Progression

Laurence Viollet, Valérie Monceaux, Frédéric Petit, Raphaël Ho Tsong Fang, Marie-Christine Cumont, Bruno Hurtrel, and Jérôme Estaquier
J Immunol 2006 177: 6685-6694. [Abstract] [Full Text] [PDF]  

Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation

Rodrigo Pacheco, Harold Oliva, José M. Martinez-Navío, Núria Climent, Francisco Ciruela, José M. Gatell, Teresa Gallart, Josefa Mallol, Carmen Lluis, and Rafael Franco
J Immunol 2006 177: 6695-6704. [Abstract] [Full Text] [PDF]  

Quantification of Repertoire Diversity of Influenza-Specific Epitopes with Predominant Public or Private TCR Usage

Katherine Kedzierska, E. Bridie Day, Jing Pi, Stephen B. Heard, Peter C. Doherty, Stephen J. Turner, and Stanley Perlman
J Immunol 2006 177: 6705-6712. [Abstract] [Full Text] [PDF]  

CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23⁺CD5⁺ B Cells

Hu Chunsong, He Yuling, Wang Li, Xiong Jie, Zhou Gang, Zhang Qiuping, Gao Qingping, Zhang Kejian, Qiao Li, Alfred E. Chang, Jin Youxin, and Tan Jinquan
J Immunol 2006 177: 6713-6722. [Abstract] [Full Text] [PDF]  

E2-2 Regulates the Expansion of Pro-B Cells and Follicular versus Marginal Zone Decisions

Ingela Wikström, Johan Forssell, Mario Goncalves, Francesco Colucci, and Dan Holmberg
J Immunol 2006 177: 6723-6729. [Abstract] [Full Text] [PDF]  

Human Bone Marrow: A Reservoir for "Enhanced Effector Memory" CD8⁺ T Cells with Potent Recall Function

Xiaoyu Zhang, Haidong Dong, Wei Lin, Stephen Voss, Lucinda Hinkley, Melissa Westergren, Guoliang Tian, Daniel Berry, David Lewellen, Richard G. Vile, Lieping Chen, Donna L. Farber, and Scott E. Strome
J Immunol 2006 177: 6730-6737. [Abstract] [Full Text] [PDF]  

CD8 T Cell Recall Responses Are Regulated by the Tissue Tropism of the Memory Cell and Pathogen

Kimberly D. Klonowski, Amanda L. Marzo, Kristina J. Williams, Seung-Joo Lee, Quynh-Mai Pham, and Leo Lefrançois
J Immunol 2006 177: 6738-6746. [Abstract] [Full Text] [PDF]  

CD4⁺ T Cells in the Absence of the CD8⁺ Cytotoxic T Cells Are Critical and Sufficient for NKT Cell-Dependent Tumor Rejection

Changwan Hong, Hyunji Lee, Mihwa Oh, Chang-Yuil Kang, Seokmann Hong, and Se-Ho Park
J Immunol 2006 177: 6747-6757. [Abstract] [Full Text] [PDF]  

Hepatitis C Virus (HCV) Core Protein-Induced, Monocyte-Mediated Mechanisms of Reduced IFN- and Plasmacytoid Dendritic Cell Loss in Chronic HCV Infection

Angela Dolganiuc, Serena Chang, Karen Kodys, Pranoti Mandrekar, Gennadiy Bakis, Maureen Cormier, and Gyongyi Szabo
J Immunol 2006 177: 6758-6768. [Abstract] [Full Text] [PDF]  

Melan-A/MART-1-Specific CD4 T Cells in Melanoma Patients: Identification of New Epitopes and Ex Vivo Visualization of Specific T Cells by MHC Class II Tetramers

Gilles Bioley, Camilla Jandus, Sandra Tuyaerts, Donata Rimoldi, William W. Kwok, Daniel E. Speiser, Jean-Marie Tiercy, Kris Thielemans, Jean-Charles Cerottini, and Pedro Romero
J Immunol 2006 177: 6769-6779. [Abstract] [Full Text] [PDF]  

T Regulatory and Primed Uncommitted CD4 T Cells Express CD73, Which Suppresses Effector CD4 T Cells by Converting 5'-Adenosine Monophosphate to Adenosine

James J. Kobie, Pranav R. Shah, Li Yang, Jonathan A. Rebhahn, Deborah J. Fowell, and Tim R. Mosmann
J Immunol 2006 177: 6780-6786. [Abstract] [Full Text] [PDF]  

Activin A Functions as a Th2 Cytokine in the Promotion of the Alternative Activation of Macrophages

Kenji Ogawa, Masayuki Funaba, Yan Chen, and Masafumi Tsujimoto
J Immunol 2006 177: 6787-6794. [Abstract] [Full Text] [PDF]  

The Wild-Type Sequence (wt) p53_25–35 Peptide Induces HLA-DR7 and HLA-DR11-Restricted CD4⁺ Th Cells Capable of Enhancing the Ex Vivo Expansion and Function of Anti-wt p53_264–272 Peptide CD8⁺ T Cells

Daisuke Ito, Andreas Albers, Yong Xiang Zhao, Carmen Visus, Ettore Appella, Theresa L. Whiteside, and Albert B. DeLeo
J Immunol 2006 177: 6795-6803. [Abstract] [Full Text] [PDF]  

TCR Genes Direct MHC Restriction in the Potent Human T Cell Response to a Class I-Bound Viral Epitope

John J. Miles, Natalie A. Borg, Rebekah M. Brennan, Fleur E. Tynan, Lars Kjer-Nielsen, Sharon L. Silins, Melissa J. Bell, Jacqueline M. Burrows, James McCluskey, Jamie Rossjohn, and Scott R. Burrows
J Immunol 2006 177: 6804-6814. [Abstract] [Full Text] [PDF]  

Fc Receptor Homolog 3 Is a Novel Immunoregulatory Marker of Marginal Zone and B1 B Cells

Woong-Jai Won, Jeremy B. Foote, Mary R. Odom, Jicun Pan, John F. Kearney, and Randall S. Davis
J Immunol 2006 177: 6815-6823. [Abstract] [Full Text] [PDF]  

Adaptation of Solitary Intestinal Lymphoid Tissue in Response to Microbiota and Chemokine Receptor CCR7 Signaling

Oliver Pabst, Heike Herbrand, Michaela Friedrichsen, Sarvari Velaga, Martina Dorsch, Günter Berhardt, Tim Worbs, Andrew J. Macpherson, and Reinhold Förster
J Immunol 2006 177: 6824-6832. [Abstract] [Full Text] [PDF]  

TIRC7 Inhibits T Cell Proliferation by Modulation of CTLA-4 Expression

Grit-Carsta Bulwin, Thomas Heinemann, Volker Bugge, Michael Winter, Anke Lohan, Mirko Schlawinsky, Anke Schulze, Stephanie Wälter, Robert Sabat, Ralf Schülein, Burkhard Wiesner, Rüdiger W. Veh, Jürgen Löhler, Richard S. Blumberg, Hans-Dieter Volk, and Nalân Utku
J Immunol 2006 177: 6833-6841. [Abstract] [Full Text] [PDF]  

Microbial Immune Suppression Mediated by Direct Engagement of Inhibitory Fc Receptor

Claudia Monari, Thomas R. Kozel, Francesca Paganelli, Eva Pericolini, Stefano Perito, Francesco Bistoni, Arturo Casadevall, and Anna Vecchiarelli
J Immunol 2006 177: 6842-6851. [Abstract] [Full Text] [PDF]  

CD8⁺ IL-17-Producing T Cells Are Important in Effector Functions for the Elicitation of Contact Hypersensitivity Responses

Donggou He, Lizhi Wu, Hee Kyung Kim, Hui Li, Craig A. Elmets, and Hui Xu
J Immunol 2006 177: 6852-6858. [Abstract] [Full Text] [PDF]  

Syk Is Downstream of Intercellular Adhesion Molecule-1 and Mediates Human Rhinovirus Activation of p38 MAPK in Airway Epithelial Cells

Xiaomin Wang, Christine Lau, Shahina Wiehler, André Pow, Tony Mazzulli, Carlos Gutierrez, David Proud, and Chung-Wai Chow
J Immunol 2006 177: 6859-6870. [Abstract] [Full Text] [PDF]  

A Novel Model of Demyelinating Encephalomyelitis Induced by Monocytes and Dendritic Cells

Glaucia C. Furtado, Beatrice Piña, Frank Tacke, Stefanie Gaupp, Nico van Rooijen, Thomas M. Moran, Gwendalyn J. Randolph, Richard M. Ransohoff, Stephen W. Chensue, Cedric S. Raine, and Sergio A. Lira
J Immunol 2006 177: 6871-6879. [Abstract] [Full Text] [PDF]  

TLR4 Up-Regulation at Protein or Gene Level Is Pathogenic for Lupus-Like Autoimmune Disease

Bei Liu, Yi Yang, Jie Dai, Ruslan Medzhitov, Marina A. Freudenberg, Ping L. Zhang, and Zihai Li
J Immunol 2006 177: 6880-6888. [Abstract] [Full Text] [PDF]  

Functional Interaction of Common -Chain and Growth Hormone Receptor Signaling Apparatus

Marsilio Adriani, Corrado Garbi, Giada Amodio, Ilaria Russo, Marica Giovannini, Stefania Amorosi, Eliana Matrecano, Elena Cosentini, Fabio Candotti, and Claudio Pignata
J Immunol 2006 177: 6889-6895. [Abstract] [Full Text] [PDF]  

Pertussis Toxin Is Superior to TLR Ligands in Enhancing Pathogenic Autoimmunity, Targeted at a Neo-Self Antigen, by Triggering Robust Expansion of Th1 Cells and Their Cytokine Production

Chiaki Fujimoto, Cheng-Rong Yu, Guangpu Shi, Barbara P. Vistica, Eric F. Wawrousek, Dennis M. Klinman, Chi-Chao Chan, Charles E. Egwuagu, and Igal Gery
J Immunol 2006 177: 6896-6903. [Abstract] [Full Text] [PDF]  

Segregation of HLA-C from ICAM-1 at NK Cell Immune Synapses Is Controlled by Its Cell Surface Density

Catarina R. Almeida and Daniel M. Davis
J Immunol 2006 177: 6904-6910. [Abstract] [Full Text] [PDF]  

The Study of High-Affinity TCRs Reveals Duality in T Cell Recognition of Antigen: Specificity and Degeneracy

David L. Donermeyer, K. Scott Weber, David M. Kranz, and Paul M. Allen
J Immunol 2006 177: 6911-6919. [Abstract] [Full Text] [PDF]  

Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas Ligand-Independent Pathway

Zhu-Xu Zhang, Yuexia Ma, Hao Wang, Jacqueline Arp, Jifu Jiang, Xuyan Huang, Kathy M. He, Bertha Garcia, Joaquím Madrenas, and Robert Zhong
J Immunol 2006 177: 6920-6929. [Abstract] [Full Text] [PDF]  

Stages of Germinal Center Transit Are Defined by B Cell Transcription Factor Coexpression and Relative Abundance

Giorgio Cattoretti, Rita Shaknovich, Paula M. Smith, Hans-Martin Jäck, Vundavalli V. Murty, and Bachir Alobeid
J Immunol 2006 177: 6930-6939. [Abstract] [Full Text] [PDF]  

CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3⁺ Regulatory and Th2 Effector Lymphocytes

Dulce Soler, Tobias R. Chapman, Louis R. Poisson, Lin Wang, Javier Cote-Sierra, Mark Ryan, Alice McDonald, Sunita Badola, Eric Fedyk, Anthony J. Coyle, Martin R. Hodge, and Roland Kolbeck
J Immunol 2006 177: 6940-6951. [Abstract] [Full Text] [PDF]  

Distinct Molecular Program Imposed on CD4⁺ T Cell Targets by CD4⁺CD25⁺ Regulatory T Cells

Teresa L. Sukiennicki and Deborah J. Fowell
J Immunol 2006 177: 6952-6961. [Abstract] [Full Text] [PDF]  

Reversing Tumor Immune Suppression with Intratumoral IL-12: Activation of Tumor-Associated T Effector/Memory Cells, Induction of T Suppressor Apoptosis, and Infiltration of CD8⁺ T Effectors

Mehmet O. Kilinc, Karanvir S. Aulakh, Raji E. Nair, Stacy A. Jones, Pascale Alard, Michele M. Kosiewicz, and Nejat K. Egilmez
J Immunol 2006 177: 6962-6973. [Abstract] [Full Text] [PDF]  

Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis

Francisco Leon, Nikhat Contractor, Ivan Fuss, Thomas Marth, Edward Lahey, Shoko Iwaki, Andrea la Sala, Victoria Hoffmann, Warren Strober, and Brian L. Kelsall
J Immunol 2006 177: 6974-6982. [Abstract] [Full Text] [PDF]  

CD4⁺CXCR4^highCD69⁺ T Cells Accumulate in Lung Adenocarcinoma

Ori Wald, Uzi Izhar, Gail Amir, Shani Avniel, Yochai Bar-Shavit, Hanna Wald, Ido D. Weiss, Eithan Galun, and Amnon Peled
J Immunol 2006 177: 6983-6990. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity

Gabriele S. V. Campanella, Jan Grimm, Lindsay A. Manice, Richard A. Colvin, Benjamin D. Medoff, Gregory R. Wojtkiewicz, Ralph Weissleder, and Andrew D. Luster
J Immunol 2006 177: 6991-6998. [Abstract] [Full Text] [PDF]  

The Peptidyl-Prolyl Isomerase Pin1 Regulates Granulocyte-Macrophage Colony-Stimulating Factor mRNA Stability in T Lymphocytes

Stephane Esnault, Zhong-Jian Shen, Emily Whitesel, and James S. Malter
J Immunol 2006 177: 6999-7006. [Abstract] [Full Text] [PDF]  

V_H Replacement Rescues Progenitor B Cells with Two Nonproductive VDJ Alleles

Johannes Lutz, Werner Müller, and Hans-Martin Jäck
J Immunol 2006 177: 7007-7014. [Abstract] [Full Text] [PDF]  

HLA-B*2704, an Allotype Associated with Ankylosing Spondylitis, Is Critically Dependent on Transporter Associated with Antigen Processing and Relatively Independent of Tapasin and Immunoproteasome for Maturation, Surface Expression, and T Cell Recognition: Relationship to B*2705 and B*2706

Verónica Montserrat, Begoña Galocha, Miguel Marcilla, Miriam Vázquez, and José A. López de Castro
J Immunol 2006 177: 7015-7023. [Abstract] [Full Text] [PDF]  

IMMUNOGENETICS:

Activating Transcription Factor/cAMP Response Element Binding Protein Family Member Regulated Transcription of CD1A

Angela Colmone, Sha Li, and Chyung-Ru Wang
J Immunol 2006 177: 7024-7032. [Abstract] [Full Text] [PDF]  

Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice

Pablo A. Silveira, Harold D. Chapman, Jessica Stolp, Ellis Johnson, S. Lewis Cox, Kara Hunter, Linda S. Wicker, and David V. Serreze
J Immunol 2006 177: 7033-7041. [Abstract] [Full Text] [PDF]  

Fine Mapping of Collagen-Induced Arthritis Quantitative Trait Loci in an Advanced Intercross Line

Xinhua Yu, Kristin Bauer, Patrik Wernhoff, Dirk Koczan, Steffen Möller, Hans-Jürgen Thiesen, and Saleh M. Ibrahim
J Immunol 2006 177: 7042-7049. [Abstract] [Full Text] [PDF] Data Supplement  

HOST DEFENSE:

The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding

Pangke Yan, Masakatsu Nanamori, Meiling Sun, Caihong Zhou, Ni Cheng, Na Li, Wei Zheng, Lihua Xiao, Xin Xie, Richard D. Ye, and Ming-Wei Wang
J Immunol 2006 177: 7050-7058. [Abstract] [Full Text] [PDF]  

TLR-Dependent Induction of IFN- Mediates Host Defense against Trypanosoma cruzi

Ritsuko Koga, Shinjiro Hamano, Hirotaka Kuwata, Koji Atarashi, Masahiro Ogawa, Hajime Hisaeda, Masahiro Yamamoto, Shizuo Akira, Kunisuke Himeno, Makoto Matsumoto, and Kiyoshi Takeda
J Immunol 2006 177: 7059-7066. [Abstract] [Full Text] [PDF]  

Adoptive Transfer of CD8⁺ Dendritic Cells (DC) Isolated from Mice Infected with Chlamydia muridarum Are More Potent in Inducing Protective Immunity Than CD8^– DC

Laura Bilenki, Shuhe Wang, Jie Yang, Yijun Fan, Lei Jiao, Antony George Joyee, Xiaobing Han, and Xi Yang
J Immunol 2006 177: 7067-7075. [Abstract] [Full Text] [PDF]  

IL-10 Deficiency Promotes Increased Borrelia burgdorferi Clearance Predominantly through Enhanced Innate Immune Responses

John J. Lazarus, Michelle J. Meadows, Robert E. Lintner, and R. Mark Wooten
J Immunol 2006 177: 7076-7085. [Abstract] [Full Text] [PDF]  

NK Cell-Derived IFN- Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis

Carl G. Feng, Mallika Kaviratne, Antonio Gigliotti Rothfuchs, Allen Cheever, Sara Hieny, Howard A. Young, Thomas A. Wynn, and Alan Sher
J Immunol 2006 177: 7086-7093. [Abstract] [Full Text] [PDF]  

Human Cytomegalovirus Envelope Glycoproteins B and H Are Necessary for TLR2 Activation in Permissive Cells

Karl W. Boehme, Mario Guerrero, and Teresa Compton
J Immunol 2006 177: 7094-7102. [Abstract] [Full Text] [PDF]  

HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells

Andrew N. Harman, John Wilkinson, Chris R. Bye, Lidija Bosnjak, J. Lewis Stern, Monique Nicholle, Joey Lai, and Anthony L. Cunningham
J Immunol 2006 177: 7103-7113. [Abstract] [Full Text] [PDF]  

Flavivirus Activation of Plasmacytoid Dendritic Cells Delineates Key Elements of TLR7 Signaling beyond Endosomal Recognition

Jennifer P. Wang, Ping Liu, Eicke Latz, Douglas T. Golenbock, Robert W. Finberg, and Daniel H. Libraty
J Immunol 2006 177: 7114-7121. [Abstract] [Full Text] [PDF]  

Sertoli Cells Initiate Testicular Innate Immune Responses through TLR Activation

Anna Riccioli, Donatella Starace, Roberta Galli, Andrea Fuso, Sigfrido Scarpa, Fioretta Palombi, Paola De Cesaris, Elio Ziparo, and Antonio Filippini
J Immunol 2006 177: 7122-7130. [Abstract] [Full Text] [PDF]  

Bordetella bronchiseptica Modulates Macrophage Phenotype Leading to the Inhibition of CD4⁺ T Cell Proliferation and the Initiation of a Th17 Immune Response

Nicholas A. Siciliano, Jason A. Skinner, and Ming H. Yuk
J Immunol 2006 177: 7131-7138. [Abstract] [Full Text] [PDF]  

Prenatal Malaria Immune Experience Affects Acquisition of Plasmodium falciparum Merozoite Surface Protein-1 Invasion Inhibitory Antibodies during Infancy

Arlene Dent, Indu Malhotra, Peter Mungai, Eric Muchiri, Brendan S. Crabb, James W. Kazura, and Christopher L. King
J Immunol 2006 177: 7139-7145. [Abstract] [Full Text] [PDF]  

Cytosolic Localization of Listeria monocytogenes Triggers an Early IFN- Response by CD8⁺ T Cells That Correlates with Innate Resistance to Infection

Sarah E. F. D’Orazio, Matthew J. Troese, and Michael N. Starnbach
J Immunol 2006 177: 7146-7154. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Lipopolysaccharide-Activated CD4⁺CD25⁺ T Regulatory Cells Inhibit Neutrophil Function and Promote Their Apoptosis and Death

Przemyslaw Lewkowicz, Natalia Lewkowicz, Andrzej Sasiak, and Henryk Tchórzewski
J Immunol 2006 177: 7155-7163. [Abstract] [Full Text] [PDF]  

Airway Epithelial Cells Produce B Cell-Activating Factor of TNF Family by an IFN--Dependent Mechanism

Atsushi Kato, Ai Q. Truong-Tran, Alan L. Scott, Kenji Matsumoto, and Robert P. Schleimer
J Immunol 2006 177: 7164-7172. [Abstract] [Full Text] [PDF]  

IL-1 and TNF- Regulation of the Adenosine Receptor (A_2A) Expression: Differential Requirement for NF-B Binding to the Proximal Promoter

Silvana Morello, Kazuhiro Ito, Satoshi Yamamura, Kang-Yun Lee, Elen Jazrawi, Patricia DeSouza, Peter Barnes, Carla Cicala, and Ian M. Adcock
J Immunol 2006 177: 7173-7183. [Abstract] [Full Text] [PDF]  

Extracellular Heat Shock Protein-70 Induces Endotoxin Tolerance in THP-1 Cells

Rajesh Aneja, Kelli Odoms, Katherine Dunsmore, Thomas P. Shanley, and Hector R. Wong
J Immunol 2006 177: 7184-7192. [Abstract] [Full Text] [PDF]  

A JNK-Independent Signaling Pathway Regulates TNF-Stimulated, c-Jun-Driven FRA-1 Protooncogene Transcription in Pulmonary Epithelial Cells

Pavan Adiseshaiah, Dhananjaya V. Kalvakolanu, and Sekhar P. Reddy
J Immunol 2006 177: 7193-7202. [Abstract] [Full Text] [PDF]  

Bruton’s Tyrosine Kinase Is Required for TLR-Induced IL-10 Production

Nathan W. Schmidt, Vivian T. Thieu, Brandon A. Mann, Ayele-Nati N. Ahyi, and Mark H. Kaplan
J Immunol 2006 177: 7203-7210. [Abstract] [Full Text] [PDF]  

A Novel Role of Hypoxia-Inducible Factor in Cobalt Chloride- and Hypoxia-Mediated Expression of IL-8 Chemokine in Human Endothelial Cells

Kyoung S. Kim, Vikram Rajagopal, Caryn Gonsalves, Cage Johnson, and Vijay K. Kalra
J Immunol 2006 177: 7211-7224. [Abstract] [Full Text] [PDF]  

Urothelial CD44 Facilitates Escherichia coli Infection of the Murine Urinary Tract

Kasper M. A. Rouschop, Marc Sylva, Gwendoline J. D. Teske, Inge Hoedemaeker, Steven T. Pals, Jan J. Weening, Tom van der Poll, and Sandrine Florquin
J Immunol 2006 177: 7225-7232. [Abstract] [Full Text] [PDF]  

Systemic Inhibition of the Angiotensin-Converting Enzyme Limits Lipopolysaccharide-Induced Lung Neutrophil Recruitment through Both Bradykinin and Angiotensin II-Regulated Pathways

Patrick G. Arndt, Scott K. Young, Katie R. Poch, Jerry A. Nick, Sandor Falk, Robert W. Schrier, and G. Scott Worthen
J Immunol 2006 177: 7233-7241. [Abstract] [Full Text] [PDF]  

Metalloproteinases Control Brain Inflammation Induced by Pertussis Toxin in Mice Overexpressing the Chemokine CCL2 in the Central Nervous System

Henrik Toft-Hansen, Richard Buist, Xue-Jun Sun, Angela Schellenberg, James Peeling, and Trevor Owens
J Immunol 2006 177: 7242-7249. [Abstract] [Full Text] [PDF]  

Chronic Hyperglycemia Predisposes to Exaggerated Inflammatory Response and Leukocyte Dysfunction in Akita Mice

Robert Gyurko, Camille C. Siqueira, Nathaniel Caldon, Li Gao, Alpdogan Kantarci, and Thomas E. Van Dyke
J Immunol 2006 177: 7250-7256. [Abstract] [Full Text] [PDF]  

Involvement of the Purinergic P2X₇ Receptor in the Formation of Multinucleated Giant Cells

Irma Lemaire, Simonetta Falzoni, Natacha Leduc, Bin Zhang, Patrizia Pellegatti, Elena Adinolfi, Paola Chiozzi, and Francesco Di Virgilio
J Immunol 2006 177: 7257-7265. [Abstract] [Full Text] [PDF]  

Complement-Dependent P-Selectin Expression and Injury following Ischemic Stroke

Carl Atkinson, Hong Zhu, Fei Qiao, Juan Carlos Varela, Jin Yu, Hongbin Song, Mark S. Kindy, and Stephen Tomlinson
J Immunol 2006 177: 7266-7274. [Abstract] [Full Text] [PDF]  

Evidence of a Functional Role for Mast Cells in the Development of Type 1 Diabetes Mellitus in the BioBreeding Rat

Rhonda Geoffrey, Shuang Jia, Anne E. Kwitek, Jeffrey Woodliff, Soumitra Ghosh, Åke Lernmark, Xujing Wang, and Martin J. Hessner
J Immunol 2006 177: 7275-7286. [Abstract] [Full Text] [PDF] Data Supplement  

FcR-Bearing Myeloid Cells Are Responsible for Triggering Murine Lupus Nephritis

Amy Bergtold, Anamika Gavhane, Vivette D’Agati, Michael Madaio, and Raphael Clynes
J Immunol 2006 177: 7287-7295. [Abstract] [Full Text] [PDF]  

The Chemokine Decoy Receptor M3 Blocks CC Chemokine Ligand 2 and CXC Chemokine Ligand 13 Function In Vivo

Andrea P. Martin, Claudia Canasto-Chibuque, Limin Shang, Barrett J. Rollins, and Sergio A. Lira
J Immunol 2006 177: 7296-7302. [Abstract] [Full Text] [PDF]  

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Fernando O. Martinez, Siamon Gordon, Massimo Locati, and Alberto Mantovani
J Immunol 2006 177: 7303-7311. [Abstract] [Full Text] [PDF] Data Supplement  

Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation

Kendra J. Greenlee, David B. Corry, David A. Engler, Risë K. Matsunami, Philippe Tessier, Richard G. Cook, Zena Werb, and Farrah Kheradmand
J Immunol 2006 177: 7312-7321. [Abstract] [Full Text] [PDF]  

Expression and Functions of the Vascular Endothelial Growth Factors and Their Receptors in Human Basophils

Amato de Paulis, Nella Prevete, Isabella Fiorentino, Francesca Wanda Rossi, Stefania Staibano, Nunzia Montuori, Pia Ragno, Amelia Longobardi, Bianca Liccardo, Arturo Genovese, Domenico Ribatti, Andrew F. Walls, and Gianni Marone
J Immunol 2006 177: 7322-7331. [Abstract] [Full Text] [PDF]  

Inhibition of Helicobacter hepaticus-Induced Colitis by IL-10 Requires the p50/p105 Subunit of NF-B

Michal F. Tomczak, Susan E. Erdman, Anne Davidson, Yan Yan Wang, Prashant R. Nambiar, Arlin B. Rogers, Barry Rickman, David Luchetti, James G. Fox, and Bruce H. Horwitz
J Immunol 2006 177: 7332-7339. [Abstract] [Full Text] [PDF]  

Major Basic Protein Homolog (MBP2): A Specific Human Eosinophil Marker

Douglas A. Plager, David A. Loegering, James L. Checkel, Junger Tang, Gail M. Kephart, Patricia L. Caffes, Cheryl R. Adolphson, Lyo E. Ohnuki, and Gerald J. Gleich
J Immunol 2006 177: 7340-7345. [Abstract] [Full Text] [PDF]  

Induction of Tolerance to Innocuous Inhaled Antigen Relies on a CCR7-Dependent Dendritic Cell-Mediated Antigen Transport to the Bronchial Lymph Node

Gabriele Hintzen, Lars Ohl, Maria-Luisa del Rio, Jose-Ignacio Rodriguez-Barbosa, Oliver Pabst, Jessica R. Kocks, Janet Krege, Svenja Hardtke, and Reinhold Förster
J Immunol 2006 177: 7346-7354. [Abstract] [Full Text] [PDF]  

Porcine Endothelial Cells and Iliac Arteries Transduced with AdenoIL-4 Are Intrinsically Protected, through Akt Activation, against Immediate Injury Caused by Human Complement

Sylvester M. Black, John F. Grehan, Andrew L. Rivard, Barbara A. Benson, Andrea E. Wahner, Alisa E. Koch, Brett K. Levay-Young, and Agustin P. Dalmasso
J Immunol 2006 177: 7355-7363. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Epitope Specificity of Autoreactive T and B Cells Associated with Experimental Autoimmune Encephalomyelitis and Optic Neuritis Induced by Oligodendrocyte-Specific Protein in SJL/J Mice

Nathali Kaushansky, Ming-Chao Zhong, Nicole Kerlero de Rosbo, Romana Hoeftberger, Hans Lassmann, and Avraham Ben-Nun
J Immunol 2006 177: 7364-7376. [Abstract] [Full Text] [PDF]  

A Single Amino Acid Difference within the -2 Domain of Two Naturally Occurring Equine MHC Class I Molecules Alters the Recognition of Gag and Rev Epitopes by Equine Infectious Anemia Virus-Specific CTL

Robert H. Mealey, Jae-Hyung Lee, Steven R. Leib, Matt H. Littke, and Travis C. McGuire
J Immunol 2006 177: 7377-7390. [Abstract] [Full Text] [PDF]  

Severe Focal Sialadenitis and Dacryoadenitis in NZM2328 Mice Induced by MCMV: A Novel Model for Human Sjögren’s Syndrome

Yukiko Ohyama, Virginia A. Carroll, Umesh Deshmukh, Felicia Gaskin, Michael G. Brown, and Shu Man Fu
J Immunol 2006 177: 7391-7397. [Abstract] [Full Text] [PDF]  

CD4⁺CD25^high T Cells Are Enriched in the Tumor and Peripheral Blood of Prostate Cancer Patients

Ashley M. Miller, Kajsa Lundberg, Volkan Özenci, Alison H. Banham, Magnus Hellström, Lars Egevad, and Pavel Pisa
J Immunol 2006 177: 7398-7405. [Abstract] [Full Text] [PDF]  

Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection

Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath
J Immunol 2006 177: 7406-7415. [Abstract] [Full Text] [PDF]  

Atorvastatin Restores Lck Expression and Lipid Raft-Associated Signaling in T Cells from Patients with Systemic Lupus Erythematosus

Elizabeth C. Jury, David A. Isenberg, Claudia Mauri, and Michael R. Ehrenstein
J Immunol 2006 177: 7416-7422. [Abstract] [Full Text] [PDF]  

Role of MHC-Linked Genes in Autoantigen Selection and Renal Disease in a Murine Model of Systemic Lupus Erythematosus

Hideharu Sekine, Kareem L. Graham, Shenru Zhao, Margaret K. Elliott, Philip Ruiz, Paul J. Utz, and Gary S. Gilkeson
J Immunol 2006 177: 7423-7434. [Abstract] [Full Text] [PDF]  

Thrice-Weekly Low-Dose Rituximab Decreases CD20 Loss via Shaving and Promotes Enhanced Targeting in Chronic Lymphocytic Leukemia

Michael E. Williams, John J. Densmore, Andrew W. Pawluczkowycz, Paul V. Beum, Adam D. Kennedy, Margaret A. Lindorfer, Susan H. Hamil, Jane C. Eggleton, and Ronald P. Taylor
J Immunol 2006 177: 7435-7443. [Abstract] [Full Text] [PDF]  

Modulation of Autoimmunity by TLR9 in the Chronic Graft-vs-Host Model of Systemic Lupus Erythematosus

Zhongjie Ma, Fangqi Chen, Michael P. Madaio, Philip L. Cohen, and Robert A. Eisenberg
J Immunol 2006 177: 7444-7450. [Abstract] [Full Text] [PDF]  

Defective Th1 Cytokine Gene Transcription in CD4⁺ and CD8⁺ T Cells from Wiskott-Aldrich Syndrome Patients

Sara Trifari, Giovanni Sitia, Alessandro Aiuti, Samantha Scaramuzza, Francesco Marangoni, Luca G. Guidotti, Silvana Martino, Paola Saracco, Luigi D. Notarangelo, Maria-Grazia Roncarolo, and Loïc Dupré
J Immunol 2006 177: 7451-7461. [Abstract] [Full Text] [PDF]  

Modulation of the Immune Response Induced by Gene Electrotransfer of a Hepatitis C Virus DNA Vaccine in Nonhuman Primates

Stefania Capone, Immacolata Zampaglione, Alessandra Vitelli, Monica Pezzanera, Lisa Kierstead, Janine Burns, Lionello Ruggeri, Mirko Arcuri, Manuela Cappelletti, Annalisa Meola, Bruno Bruni Ercole, Rosalba Tafi, Claudia Santini, Alessandra Luzzago, Tong-Ming Fu, Stefano Colloca, Gennaro Ciliberto, Riccardo Cortese, Alfredo Nicosia, Elena Fattori, and Antonella Folgori
J Immunol 2006 177: 7462-7471. [Abstract] [Full Text] [PDF]  

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