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On the cover: Relative probability of a given germline amino acid type to mutate to other types on the antigen-contacting surface of maturing antibodies. Comparison of a simple model (square color) to data (circle color) derived from thousands of antibody sequences shows mutations that are favored above random during the somatic hypermutation process. Clark, L. A., S. Ganesan, S. Papp, and H. W. T. van Vlijmen. 2006. Trends in antibody sequence changes during the somatic hypermutation process. J. Immunol. 177: 333-340.
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